7315-74-4

Upstream product

• 67-56-1 methanol 
• 7287-81-2 1-(m-methylphenyl)ethanol 

Downstream Products

• 5160-99-6 1-iso-butyl-3-methylbenzene 
• 68102-26-1 2-Methyl-3-(m-tolyl)-3-bromopropan 
• 68102-31-8 3-(2-Isobutyl-4-methyl-phenyl)-2-naphthalen-2-yl-pentanedioic acid 
• 68135-51-3 Ethyl-α-(2-naphthyl)-4b-(2'-isobutyl-4'-methylphenyl)-glutarate 
• 68102-28-3 2-isobutyl-4-methylbenzaldehyde 
• 68102-27-2 1-(chloromethyl)-2-isobutyl-4-methylbenzene 
• 68102-29-4 2-Isobutyl-4-methylzimtsaeure 
• 68102-36-3 β-(2-Isobutyl-4-methylphenyl)-propionic acid 
• 7315-81-3 ν-(2-Isobutyl-4-methylphenyl)-buttersaeure 
• 68102-30-7 2-Isobutyl-4-methylzimtsaeure-ethylester 
• 68102-34-1 2-(2'-Isobutyl-4'-methylphenyl)-1,2,3,4-tetrahydrophenanthrene-1-carboxylic acid 
• 7315-79-9 2-Isobutyl-4-methyl-acetophenon 
• 7315-76-6 3-(2-Isobutyl-4-methyl-benzoyl)-propionsaeure 
• 7315-78-8 3-(2-Isobutyl-4-methyl-benzoyl)-propionsaeure-aethylester 

Relevant academic research and scientific papers

Highly efficient NHC-iridium-catalyzed β-methylation of alcohols with methanol at low catalyst loadings

The methylation of alcohols is of great importance since a broad number of bioactive and pharmaceutical alcohols contain methyl groups. Here, a highly efficient β-methylation of primary and secondary alcohols with methanol has been achieved by using bis-N-heterocyclic carbene iridium (bis-NHC-Ir) complexes. Broad substrate scope and up to quantitative yields were achieved at low catalyst loadings with only hydrogen and water as by-products. The protocol was readily extended to the β-alkylation of alcohols with several primary alcohols. Control experiments, along with DFT calculations and crystallographic studies, revealed that the ligand effect is critical to their excellent catalytic performance, shedding light on more challenging Guerbet reactions with simple alcohols. [Figure not available: see fulltext.].