73151-17-4

Upstream product

• 46503-52-0 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanone 
• 2631-72-3 2,4-dichlorophenacyl bromide 
• 1667-11-4 biphenyl-4-methylchloride 
• 24155-42-8 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol 

Relevant academic research and scientific papers

A new series of miconazole analogs: Synthesis and in vitro antifungal and antimycobacterial activities

The synthesis and antimicrobial activity of new miconazole analogs are reported. All compounds showed good antimycobacterial activity; some of them were also active against some strains of Candida albicans and Candida sp.. Of the synthesized compounds, two showed good activity both against some strains of Mycobacterium and some strains of Candida. Structure-activity relationships are discussed.

New α-aryl-β,N-imidazolylethyl benzyl and naphthylmethyl ethers with antimycotic and antibacterial activity

A new series of α-aryl-β,N-imidazolylethyl benzyl and naphthylmethyl ethers was synthesized and tested for antimycotic and antimicrobial activity. All compounds showed antifungal activity; most of them were also active against gram-positive bacteria, whereas no activity was detected against gram-negative bacteria. Structure-activity relationships are discussed. The α-(2,4-dichlorophenyl)-β,N-imidazolylethyl 4-phenylthiobenzyl ether nitrate (8), which showed good ski tolerability and in vivo antimycotic activity comparable with or better than 1-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazole (miconazole) and 1-[α-(o-chlorophenyl)benzhydryl]imidazole (clotrimazole), was selected for further researches.