73183-24-1

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 105-07-7 4-cyanobenzaldehyde 

Downstream Products

• 73183-22-9 4-(1-Cyano-2,2-dimethyl-4-oxo-1-trimethylsilanyloxy-pentyl)-benzonitrile 
• 93554-86-0 4-(Amino-cyano-methyl)-benzonitrile; hydrochloride 
• 104876-67-7 (4-Cyanphenyl)-2,4,6-cycloheptatrien-1-ylketon 
• 121986-03-6 α-(4-cyanophenyl)-α-hydroxyacetonitrile 
• 60694-99-7 1-(4-cyanophenyl)-2-phenylethan-1-one 
• 3032-92-6 4-cyanophenylacetylene 
• 1424280-47-6 C₂₇H₄₁NO₄Si 
• 73183-27-4 4-(2,2-Dimethyl-1,4-dioxopentyl)benzonitril 
• 104876-63-3 (4-Cyanphenyl)-2,4,6-cycloheptatrien-1-yl(trimethylsiloxy)acetonitril 
• 73183-28-5 4-(3-Oxocyclohexylcarbonyl)benzonitril 

Relevant academic research and scientific papers

A 3D In(III) coordination polymer derived from rigid dicarboxylate ligand: Synthesis, crystal structure and catalytic property

A new indium coordination polymer, In(OH)(H2O)(1,4-bdc) (1,4-H2bdc = 1, 4-benzendicarboxylic acid), has been prepared under solvothermal conditions using a mixture of rigid organic linker and inorganic heteropolyacid (12-phosphotungs

A two-dimensional manganese coordination polymer: Crystal structure, proton conductivity and catalytic property

Herein, we report a new Manganese coordination polymer, Mn3L2(H2O)4·2H2O (1), based on the 4′-(1-H-tetrazol-5-yl)-[1,1′-biphenyl]-3,5-dicarboxylic acid (H3L) ligand under solvothermal condi

Crystal transformation in Mn(ii) metal-organic frameworks based on a one-dimensional chain precursor

The solvothermal reaction of Mn(ii) salts and 5-((4′-(tetrazol-5′′-yl)benzyl)oxy)isophthalic acid (H3L) affords an Mn(ii) based coordination polymer Mn(H2L)2(H2O)2(1), which possesses a one-dimensiona

Role of metal center and coordination environment in M-(Z)-N-((E)-pyridin-2-ylmethylene)isonicotinohydrazonate (M = LaIII, ZnII, CdII or HgII) catalyzed cyanosilylation of aldehydes

A series of known metal complexes, [LaL2(NO3)(H2O)2]·5H2O (1), [Zn(μ-L)(NO3)(H2O)]n (2), {[Cd2(μ-HL)(μ-L)(NO3)3(H2O)]·Hsub

Application of an Electrochemical Microflow Reactor for Cyanosilylation: Machine Learning-Assisted Exploration of Suitable Reaction Conditions for Semi-Large-Scale Synthesis

Cyanosilylation of carbonyl compounds provides protected cyanohydrins, which can be converted into many kinds of compounds such as amino alcohols, amides, esters, and carboxylic acids. In particular, the use of trimethylsilyl cyanide as the sole carbon source can avoid the need for more toxic inorganic cyanides. In this paper, we describe an electrochemically initiated cyanosilylation of carbonyl compounds and its application to a microflow reactor. Furthermore, to identify suitable reaction conditions, which reflect considerations beyond simply a high yield, we demonstrate machine learning-assisted optimization. Machine learning can be used to adjust the current and flow rate at the same time and identify the conditions needed to achieve the best productivity.

An uncoordinated tertiary nitrogen based tricarboxylate calcium network with Lewis acid-base dual catalytic sites for cyanosilylation of aldehydes

The design and utilization of dual sites for synergistic catalysts has been recognised as an efficient method towards high-efficiency catalysis in the cyanosilylation of aldehydes, which gives key intermediates for the synthesis of a number of valuable na

Organo-catalyzed Michael addition of 2-fluoro-2-arylacetonitriles

An efficient synthesis of a variety of 2-arylacetonitriles containing a fluorinated stereogenic center through organo-catalyzed Michael addition reaction of 2-fluoro-2-arylacetonitriles has been developed. This protocol uses a cheap organocatalyst (DBU) and has a broad substrate scope: α, β-unsaturated ketones, esters, nitriles and sulfones were all successfully reacted. Importantly, water proved to be a good solvent for this reaction.

Multinuclear transition metal-containing polyoxometalates constructed from Nb/W mixed-addendum precursors: synthesis, structures and catalytic performance

Four new transition metal-containing Nb/W mixed-addendum POM trimers with the formula H19[M4(H2O)x(P2W15Nb3O62)3]·m(HCOOH)·nH2O (M = Cu,x= 15,m=

Germyliumylidene: A Versatile Low Valent Group 14 Catalyst

Bis-NHC stabilized germyliumylidenes [RGe(NHC)2]+ are typically Lewis basic (LB) in nature, owing to their lone pair and coordination of two NHCs to the vacant p-orbitals of the germanium center. However, they can also show Lewis acidity (LA) via Ge?CNHC σ* orbital. Utilizing this unique electronic feature, we report the first example of bis-NHC-stabilized germyliumylidene [MesTerGe(NHC)2]Cl (1), (MesTer=2,6-(2,4,6-Me3C6H2)2C6H3; NHC= IMe4=1,3,4,5-tetramethylimidazol-2-ylidene) catalyzed reduction of CO2 with amines and arylsilane, which proceeds via its Lewis basic nature. In contrast, the Lewis acid nature of 1 is utilized in the catalyzed hydroboration and cyanosilylation of carbonyls, thus highlighting the versatile ambiphilic nature of bis-NHC stabilized germyliumylidenes.

n-Butyllithium as a highly efficient precatalyst for cyanosilylation of aldehydes and ketones

A highly efficient cyanosilylation protocol mediated by the easily availablen-BuLi with a wide range of aldehydes and ketones was developed. This protocol features excellent yields with very lown-BuLi loadings (0.01-0.05 mol%) at room temperature, solvent