73187-30-1

Basic information

• Product Name: (1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
• Synonyms: (1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone;1-(1H-Indol-2-ylcarbonyl)-4-methylpiperazine
• CAS NO: 73187-30-1
• Molecular Formula: C14H17N3O
• Molecular Weight: 243
• Mol File: 73187-30-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 175-176℃
• Appearance: /
• Density: 1.228
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone(73187-30-1)
• EPA Substance Registry System: (1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone(73187-30-1)

Safety Data

• Hazardous Substances Data: 73187-30-1(Hazardous Substances Data)

Usage

General Description

(1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone is a chemical compound with the molecular formula C15H18N4O. It is a derivative of indole and piperazine, two important organic compounds, and it has potential pharmacological properties. (1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone has been studied for its potential use as a psychoactive drug, and it may have applications in the treatment of neurological disorders or as a research tool for studying the brain and behavior. Its precise mechanisms of action and potential therapeutic uses are still being investigated, but its unique structure and potential biological activity make it an interesting target for further research in the field of medicinal chemistry and pharmacology.

Upstream product

• 109-01-3 1-methyl-piperazine 
• 1477-50-5 Indole-2-carboxylic acid 

Relevant articles and documents

In vitro antibacterial and antifungal activity and computational evaluation of novel indole derivatives containing 4-substituted piperazine moieties

Background: Lack of specificity and occurence of resistance to current antibacterial and antifungal agents are major shortcomings for the treatment of microbial diseases. Finding novel antimicrobial agents is therefore highly needed to develop more potent drugs. Within this framework, several indole derivatives were designed and reported in the literature. Methods: In vitro antibacterial and antifungal activities of previously synthesized novel indole compounds containing 4-substituted piperazine moieties were tested against Staphylococcus aureus (ATCC 25923), Methicilline resistant Staphylococcus aureus (MRSA, ATCC 43300), Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 6633) and Candida albicans (ATTC 10231). Sultamicillin T, ampicillin, ciprofloxacin and fluconazole were used as positive controls. Molecular docking was used to study the interaction of active compounds with their receptor. Results: Fifteen compounds were synthesized and their antibacterial activities were similar to that of the reference drugs used as controls. Compounds 4 and 15 were more active (MIC 25 μg/ml) than ampicillin (MIC 50 μg/ml) against MRSA, while they showed the same activity as sultamicillin T (MIC 25 μg/ml). All compounds showed lower activity than ciprofloxacin (MIC 25 μg/ml) against the tested microorganisms. However, none of the compounds showed remarkable antifungal activity against C. albicans. Conclusion: Compound 6 showed the best interaction with the amino acid residues of the targeted cofactor NAD+.

HETEROCYCLIC COMPOUNDS

Heterocyclic compounds and methods of making them and using them.

USE OF INDOLYL DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT ALLERGIC RHINITIS

A method to treat allergic rhinitis is disclosed in which patients are administered certain indolyl compounds.