73224-21-2Relevant academic research and scientific papers
Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: A structure-activity study
Wimalasena, D. Shyamali,Perera, Rohan P.,Heyen, Bruce J.,Balasooriya, Inoka S.,Wimalasena, Kandatege
, p. 760 - 768 (2008/09/19)
The active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), N-methyl-4-phenylpyridinium (MPP+), selectively destroys the dopaminergic neurons and induces the symptoms of Parkinson's disease. Inhibition of mitochondrial complex
Allylprodine Analogues as Receptor Probes. Evidence That Phenolic and Nonphenolic Ligands Interact with Different Subsites on Identical Opioid Receptors
Portoghese, Philip S.,Alreja, Bipin D.,Larson, Dennis L.
, p. 782 - 787 (2007/10/02)
The m-hydroxy analogues of allylprodine and related structures have been synthesized and tested for narcotic agonist and antagonist activity on the electrically stimulated guinea pig ileum and by the hot-plate procedure in mice.It has been found that m-hy
