73224-20-1

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 2398-37-0 3-methoxyphenyl bromide 
• 598-30-1 sec.-butyllithium 

Downstream Products

• 73224-22-3 1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine 
• 73224-21-2 1-methyl-4-hydroxy-4-(3-hydroxyphenyl)piperidine 
• 97966-12-6 (3R,4R)-4-(3-Methoxy-phenyl)-1,3-dimethyl-4-propyl-piperidine 
• 97966-12-6 picenadol methyl ether 
• 79201-85-7 3-((3R,4R)-1,3-Dimethyl-4-propyl-piperidin-4-yl)-phenol 
• 97966-11-5 (+/-)-1,4,5,6-tetrahydro-4-(3-methoxyphenyl)-N,N,1-trimethyl-4-propyl-3-pyridinemethaneamine 
• 79201-85-7 picenadol 
• 105223-62-9 3-(1-Methyl-1,2,3,6-tetrahydro-[4]pyridyl)-phenol 

Relevant academic research and scientific papers

Synthesis of Picenadol via Metalloenamine Alkylation Methodology

A convenient synthesis of the novel phenylpiperidine analgesic agent picenadol, (+/-)-1, via tetrahydropyridine 2 is described.Tetrahydropyridine 7, prepared from 6 via metalation (n-butyllithium) and alkylation with 1-bromopropane, could not be directly

Processes for preparing picenadol precursors and novel intermediates thereof

The present invention relates to processes for preparing precursors of picenadol, (±)3-(1,3α-dimethyl-4α-propyl-4β-piperidinyl)phenol, hydrochloride, a known analgesic. Certain of the compounds prepared by the present process are novel as well.

4a-Aryl-octahydro-1H-2-pyrindines

4a-phenyl and substituted phenyl 2,3,4,4a,5,6,7,7a-octahydro-1H-2-pyrindines having a 2-substituent are disclosed. Such compounds are useful as analgesic agents having mixed agonist and antagonist properties. The compounds can be prepared by reacting an a

Allylprodine Analogues as Receptor Probes. Evidence That Phenolic and Nonphenolic Ligands Interact with Different Subsites on Identical Opioid Receptors

The m-hydroxy analogues of allylprodine and related structures have been synthesized and tested for narcotic agonist and antagonist activity on the electrically stimulated guinea pig ileum and by the hot-plate procedure in mice.It has been found that m-hy

Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines

4a-Arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroquinolines analgesic agonists and antagonists are prepared doubly alkylating a 4-aryltetrahydropyridine with an α,ω-dihaloalkane.