73281-56-8

Upstream product

• 105-34-0 methyl 2-cyanoacetate 
• 105-53-3 diethyl malonate 
• 10328-92-4 N-Methylisatoic anhydride 
• 105-56-6 ethyl 2-cyanoacetate 
• 118-48-9 isatoic anhydride 
• 65740-49-0 1-methyl-3-formyl-4-hydroxy-2(1H)-quinolinone 
• 1677-46-9 4-hydroxy-1-methyl-2(1H)-quinolone 
• 105873-10-7 C₁₁H₁₀N₂O₃ 
• 119-68-6 N-Methylanthranilic acid 
• 91-40-7 2-(phenylamino)benzoic acid 

Downstream Products

• 876134-54-2 1-methyl-2-oxo-4-(triphenylphosphoranylideneamino)-1,2-dihydroquinoline-3-carbonitrile 

Relevant academic research and scientific papers

SUBSTITUTED QUINOLINONYL PIPERAZINE COMPOUNDS USEFUL AS T CELL ACTIVATORS

Disclosed are compounds of Formula (I) or a salt thereof, wherein: R1, R2, R3, R4, R5, R6, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activi

MIF INHIBITORS AND THEIR USES

The invention relates to MIF inhibitors; compositions comprising an effective amount of a MIF inhibitor; and methods for treating or preventing diseases associated with MIF.

MIF INHIBITORS AND THEIR USES

The invention relates to MIF inhibitors; compositions comprising an effective amount of a MIF inhibitor; and methods for treating or preventing diseases associated with MIF.

Synthesis of 3-amino-4,5-dihydro(5H)4-oxothieno[3,2-c]quinoline-2- carboxylic acids and their alkyl esters

4-Hydroxyquinolin-2(H)ones are converted to 4-chloro-3-cyanoquinolin-2(H) ones and are cyclised with thioglycolic acid and its alkyl esters to furnish the title compounds viz. 3-amino-4,5-dihydro(5H)4-oxothieno[3,2-c]quinoline-2- carboxylic acids and thei

A novel short-step synthesis of functionalized 4-hydroxy-2-quinolones using a 1-hydroxybenzotriazole methodology

A novel method for the synthesis of 3-substituted 4-hydroxy-1-methyl- and 1-phenyl-2-quinolones is presented. The compounds are produced in a one-step reaction in very good yields (51-76%). The major advantage of the methodology is the short time for the

Solid-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones

Cyanoacetic acid was loaded on Wang resin and C-acylated using acid anhydrides and triethylamine as base. Resin cleavage with concomitant decarboxylation produces β-keto nitriles. In the case of isatoic anhydrides, the resin-bound acylated intermediates undergo cyclative cleavage upon heating, leading to 4hydroxyquinolin-2(1H)-ones.