73282-17-4Relevant academic research and scientific papers
MediaChrom: Discovering a Class of Pyrimidoindolone-Based Polarity-Sensitive Dyes
Dell'Acqua, Monica,Ronda, Luca,Piano, Riccardo,Pellegrino, Sara,Clerici, Francesca,Rossi, Elisabetta,Mozzarelli, Andrea,Gelmi, Maria Luisa,Abbiati, Giorgio
, p. 10939 - 10954 (2015)
A small library of six polarity-sensitive fluorescent dyes, nicknamed MediaChrom, was prepared. This class of dyes is characterized by a pyrimidoindolone core fitted out with a conjugated push-pull system and a carboxy linker for a conceivable coupling wi
A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia
Sellmer, Andreas,Pilsl, Bernadette,Beyer, Mandy,Pongratz, Herwig,Wirth, Lukas,Elz, Sigurd,Dove, Stefan,Henninger, Sven Julian,Spiekermann, Karsten,Polzer, Harald,Klaeger, Susan,Kuster, Bernhard,B?hmer, Frank D.,Fiebig, Heinz-Herbert,Kr?mer, Oliver H.,Mahboobi, Siavosh
supporting information, (2020/03/24)
Mutants of the FLT3 receptor tyrosine kinase (RTK) with duplications in the juxtamembrane domain (FLT3-ITD) act as drivers of acute myeloid leukemia (AML). Potent tyrosine kinase inhibitors (TKi) of FLT3-ITD entered clinical trials and showed a promising,
SYNTHESIS, PHARMACOLOGY AND USE OF NEW AND SELECTIVE FMS-LIKE TYROSINE KINASE 3 (FLT3) FLT3 INHIBITORS
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Page/Page column 32; 33; 34, (2019/03/05)
The present invention relates to small molecule compounds of formula (I) and their use as FLT3 inhibitors for the treatment of various diseases, such as acute myeloid leukemia (AML). The present invention further relates to methods of synthesizing the com
Synthesis and reactions of N-protected 3-nitroindoles
Pelkey,Gribble
, p. 1117 - 1122 (2007/10/03)
Treatment of N-protected indoles 3 with acetyl nitrate generated in situ at low temperatures affords the corresponding 3-nitroindoles 2 in good to excellent yields. Deprotection of 1-acetyl-3-nitroindole (2h) with DBU gives 3-nitroindole (1). Reaction of
