733-85-7Relevant academic research and scientific papers
Facile synthesis of non-nucleoside compounds starting from a-chlorocarbenium ions and isocyanates as potential hiv-1 reverse transcriptase inhibitors
Hamed, Atef A.,Zeid, Ibrahim F.,Manaa, Alaa A.
experimental part, p. 555 - 564 (2010/03/03)
Chloro(phenyl)carbenium hexachloroantimonate salts react with isocyanates to afford either isoindolium (1) or benzoxazinium salts (2). Addition of one equivalent of alcohol to 2 led, after hydrolysis with aq. NaOH, to the formation of benzoxazin-2-ones 3. Treatment with a large excess of alcohol transformed the salts 1 and 2 to the corresponding isoindol-1-ones 11 and the isocyanates 5, respectively. Reaction of 5 with primary amines furnished the urea derivatives 6 in good yield. The biological activity of 6a - o against HIV-1 was determined.
