733050-12-9

Upstream product

• 1779-49-3 Methyltriphenylphosphonium bromide 
• 733050-11-8 methyl 3,5-di-O-(4-chlorobenzyl)-2-keto-α-D-ribofuranoside 
• 108008-66-8 methyl 3,5-di-O-(4-chlorobenzyl)-α-D-ribofuranoside 
• 1824-96-0 methyl ribofuranoside 
• 532-20-7 D-Ribose 

Downstream Products

• 1174639-13-4 methyl-3,5-di-O-(4-chlorobenzyl)-2-deoxy-(R)-2,2-C-(1,1-difluoroethane-1,2-diyl)-α-D-erythro-pentofuranoside 
• 1276113-04-2 methyl N6-benzoyl-2'-α-(benzoyloxymethyl)-3',5'-di-O-(4-chlorobenzyl)-2'-deoxyadenosine 
• 1276113-07-5 methyl 3',5'-di-O-(4-chlorobenzyl)-2'-deoxy-2'-(hydroxymethyl)adenosine 
• 733050-19-6 2'-α-(benzoyloxymethyl)-3',5'-di-O-(benzoyl)-2'-deoxy-N⁴-benzoylcytidine 
• 733050-35-6 2'-α-acetoxymethyl-3',5'-di-O-(4-chlorobenzyl)-2'-deoxy-N⁴-benzoylcytidine 
• 160054-76-2 5'-O-(dimethoxytrityl)-2'-deoxy-2'-α-methyl-N⁴-benzoylcytidine 
• 733050-18-5 2'-α-(tert-butyldimethylsiloxymethyl)-3',5'-di-O-(4-chlorobenzyl)-2'-deoxycytidine 
• 733050-26-5 3',5'-di-O-(tert-butyldimethylsilyl)-2'-deoxy-2'-α-methyl-N⁴-benzoylcytidine 
• 733050-16-3 2'-α-acetoxymethyl-3',5'-di-O-(4-chlorobenzyl)-2'-deoxyuridine 
• 733050-23-2 3',5'-di-O-(4-chlorobenzyl)-2'-deoxy-2'-α-iodomethyluridine 
• 733050-17-4 3',5'-di-O-(4-chlorobenzyl)-2'-deoxy-2'-α-hydroxymethylcytidine 
• 733050-21-0 3',5'-di-O-(4-chlorobenzyl)-2'-deoxy-2'-α-hydroxymethyluridine 
• 733050-22-1 3',5'-di-O-(4-chlorobenzyl)-2'-deoxy-2'-α-methyluridine 
• 733050-14-1 methyl 2α-acetoxymethyl-3,5-di-O-(4-chlorobenzyl)-2-deoxy-α-D-ribofuranoside 

Relevant academic research and scientific papers

2′-deoxy-2′-α-C-(hydroxymethyl)adenosine as potential anti-HCV agent

Because of the importance of C-branched nucleosides in the discovery of new antiviral molecules, we decided to synthesize 2′-deoxy-2′-α- C-(hydroxymethyl)adenosine as a potential anti-HCV agent. The synthesis of a new adenosine analogue following two different synthetic routes is described. The new C-branched nucleoside was tested for its antiviral activity and found to be inactive.

Synthesis of nucleosides with additional nucleobases

The syntheses of two nucleosides with additional nucleobases in the 2′-position are presented. The nucleosides have two- and one-carbon linkers to the additional nucleobase, respectively. The two nucleosides are synthesized from different strategies. The

Synthesis of the phosphoramidite derivatives of 2′-deoxy-2′-C- α-methylcytidine and 2′deoxy-2′-C- αhydroxymethylcytidine: Analogues for chemical dissection of RNA's 2′-hydroxyl group

Oligonucleotides containing 2′-C-αmethyl and 2′-C-α-hydroxymethyl modifications enable strategies for delineation of the distinctive role fulfilled by the 2′-hydroxyl group in RNA structure and function. Synthetic routes to the phosphoramidite derivatives