7331-26-2Relevant articles and documents
Pyrimethamine conjugated histone deacetylase inhibitors: Design, synthesis and evidence for triple negative breast cancer selective cytotoxicity
Wu, Bocheng,Fathi, Shaghayegh,Mortley, Shanee,Mohiuddin, Mahir,Jang, Young C.,Oyelere, Adegboyega K.
, (2020/02/18)
Signal transducer and activator of transcription 3 (STAT3) is an oncogenic transcription factor which has been recognized as a promising cancer therapeutic target. Small molecule pyrimethamine (PYM) is a known direct inhibitor of activated STAT3 and it is