73318-77-1

Upstream product

• 32025-67-5 4’-dimethylamino-2,2-diethoxyacetophenone 
• 2124-31-4 4'-dimethylaminoacetophenone 
• 586-77-6 4-bromo-N,N-dimethylaniline 

Downstream Products

• 1429621-75-9 C₂₀H₂₂N₄O 
• 1429621-83-9 C₂₁H₂₃N₃O₄ 
• 1429621-88-4 C₂₁H₂₃N₃O₄ 
• 1429621-90-8 C₂₂H₂₄N₂O₇ 
• 73384-14-2 7-(4-(dimethylamino)phenyl)pteridin-4-amine 

Relevant academic research and scientific papers

Two Sensitive Fluorescent BOPIM Probes with Tunable TICT Character for Low-Level Water Detection in Organic Solvents

Two novel Boron-fluorine derivatives bearing dimethylamino moieties, BOPIM-1 and BOPIM-2, were proposed as sensitive fluorescent sensors for low-level water quantification in organic solvents. Two BOPIMs exhibit typical phenomenon for an emission from a twisted intra-molecular charge transfer (TICT) state, the emission red shift and intensity weakening with solvent polarity. Introduction of trace amount of water to solvent resulted in fluorescent quenching, accompanied by the red shift of the emission, which was attributed to the formation of TICT excitation of BOPIMs by hydrolysis. A quantification method to detect water content was developed, described by a linear equation lg I I 0 lg frac{I}{I-0} vs. lg φ w in the range of φ w (volume fraction of water) 0.001~0.01, 0.01~0.1, respectively. The experiment results of determination of water in real 1, 4-dioxane (Diox) samples proved that this method can be used in practical application.

One-pot three-component reactions of methyl ketones, phenols and a nucleophile: An expedient way to synthesize densely substituted benzofurans

Three-component reactions of phenylglyoxal monohydrate, phenols, and indoles were developed with the aid of acid-catalyst, which produced various densely substituted benzofurans with good to excellent yields. On the basis of this observation, a one-pot, step-wise reaction was developed by using methyl ketones instead of using phenylglyoxal component in I2/DMSO system. At last, three-component reaction offered a useful way to synthesize densely substituted benzofurans starting from simple and easily available substrates. The indole component can be replaced by some other nucleophiles, such as 1,2,4-trimethoxybenzene and thiophenol.

6-(1-ACYL-1-HYDROXYMETHYL)PENICILLANIC ACID DERIVATIVES

6-(1-Acyl-1-hydroxymethyl)penicillanic acid derivatives are useful as antibacterials and/or beta-lactamase inhibitors.