73318-89-5

Usage

InChI:InChI=1/C14H18O2/c1-10(2)4-5-12-6-8-13(9-7-12)11(3)14(15)16/h4,6-9,11H,5H2,1-3H3,(H,15,16)

Upstream product

• 124-38-9 carbon dioxide 
• 925-90-6 ethylmagnesium bromide 
• 85964-33-6 1-(3-methyl-2-butenyl)-4-vinylbenzene 
• 863780-45-4 [4-(2-methylpropyl)phenyl]magnesium bromide 
• 106364-41-4 p-(3-methyl-2-butenyl)phenyl magnesium chloride 
• 23853-76-1 1-chloro-4-(3-methylbut-2-en-1-yl)benzene 
• 85475-56-5 ethyl 2-<(4-(3-methyl-2-butenyl)phenyl)>propionate 
• 73318-88-4 2-<4-(3-methyl-2-butenyl)phenyl>propionitrile 
• 51833-36-4 4-chlorophenylmagnesium chloride 
• 503-60-6 3,3-dimethyl-allyl chloride 

Downstream Products

• 64451-77-0 2-<(4-(3-methylbutyl)phenyl)>propionic acid 
• 85475-58-7 isobutyl 2-(p-prenylphenyl)propionate 
• 85475-60-1 tetrahydrofurfuryl 2-(p-prenylphenyl)propionate 
• 85475-61-2 2,3-dihydroxypropyl2-(p-prenylphenyl)propionate 
• 85475-59-8 cyclohexyl 2-(p-prenylphenyl)propionate 
• 85475-56-5 ethyl 2-<(4-(3-methyl-2-butenyl)phenyl)>propionate 
• 85475-57-6 n-butyl 2-(p-prenylphenyl)propionate 
• 73318-90-8 sodium 2-(p-prenylphenyl)propionate 

Relevant academic research and scientific papers

Effective Synthesis of 2-propionic Acid via Hydromagnesation Reaction with Nickel or Titanium Catalysts

2-propionic acid was synthesized in 82percent yield via nickel(II) chloride or dichlorobis5-cyclopentadienyl>titanium-catalyzed hydromagnesation of 1-(3-methyl-2-butenyl)-4-vinylbenzene obtained in ca. 63-68percent yield by the coupling reaction of 4-(3-methyl-2-butenyl)phenylmagnesium chloride with vinyl chloride.

A NEW CONVENIENT SYNTHESIS OF α-ARYLPROPIONIC ACID ESTERS AND α-ARYLPROPIONITRILES

Various types of α-arylpropionic acid esters were effectively obtained by the coupling reaction of aryl Grignard reagents and α-bromopropionic acid esters in the presence of nickel catalysts. α-Arylpropionitriles, precursors of α-arylpropionic acids, were also synthesized by the reaction of α-methanesulfonyloxypropionitrile and arylcopper reagents prepared from equimolar amount of arylmagnesium halides and copper(I) bromide.

Process for producing α-arylalkanoic acid ester

A process for producing an α-arylalkanoic acid ester represented by the general formula STR1 wherein Ar represents an aryl group which may optionally be substituted, and R1 and R2, independently from each other, represent a lower alkyl group, which comprises reacting a Grignard reagent prepared from an aryl halide of the general formula wherein Ar is as defined above and X1 represents a halogen atom, and magnesium, with an α-haloalkanoic acid ester of the general formula STR2 wherein R1 and R2 are as defined above, and X2 represents a halogen atom, said reaction of the Grignard reagent with the α-haloalkanoic acid ester of general formula (III) being carried out in the presence of a nickel compound.

2-(p-Prenylphenyl)propionic acid

2-(p-prenylphenyl)propionic acid and pharmaceutically acceptable salts thereof are disclosed. They exhibit anti-inflammatory and analgesic activity with low gastrointestinal action.