73323-63-4

Basic information

• Product Name: (E)-3-(2-methyl-3-nitrophenyl)propenoic acid
• Synonyms: (E)-3-(2-methyl-3-nitrophenyl)propenoic acid
• CAS NO: 73323-63-4
• Molecular Weight: 207.186
• Mol File: 73323-63-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-3-(2-methyl-3-nitrophenyl)propenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(2-methyl-3-nitrophenyl)propenoic acid(73323-63-4)
• EPA Substance Registry System: (E)-3-(2-methyl-3-nitrophenyl)propenoic acid(73323-63-4)

Safety Data

• Hazardous Substances Data: 73323-63-4(Hazardous Substances Data)

Upstream product

• 141-82-2 malonic acid 
• 23876-12-2 3-formyl-2-methyl-1-nitrobenzene 
• 23876-13-3 (2-methyl-3-nitrophenyl)methanol 
• 1975-50-4 2-methyl-3-nitrobenzic acid 
• 603-83-8 3-nitro-o-tolylamine 
• 79-10-7 acrylic acid 
• 69022-62-4 β-(2-methyl-3-nitrophenyl)-α-chloropropionic acid 

Downstream Products

• 879-50-5 3-(3-chloro-2-methylphenyl)propanoic acid 

Relevant articles and documents

Synthesis, pharmacological evaluation and docking studies of pyrrole structure-based CB2 receptor antagonists

Abstract During the last years, there has been a continuous interest in the development of cannabinoid receptor ligands that may serve as therapeutic agents and/or as experimental tools. This prompted us to design and synthesize analogues of the CB2 receptor antagonist N-fenchyl-5-(4-chloro-3-methyl-phenyl)-1-(4-methyl-benzyl)-1H-pyrazole-3-carboxamide (SR144528). The structural modifications involved the bioisosteric replacement of the pyrazole ring by a pyrrole ring and variations on the amine carbamoyl substituents. Two of these compounds, the fenchyl pyrrole analogue 6 and the myrtanyl derivative 10, showed high affinity (Ki in the low nM range) and selectivity for the CB2 receptor and both resulted to be antagonists/inverse agonists in [35S]-GTPγS binding analysis and in an in vitro CB2 receptor bioassay. Cannabinoid receptor binding data of the series allowed identifying steric constraints within the CB2 binding pocket using a study of Van der Waals' volume maps. Glide docking studies revealed that all docked compounds bind in the same region of the CB2 receptor inactive state model.

Photocyclization of 1-(1-Chloroisoquinolin-6-yl)-1H-v-triazolopyridines to 10-Chloro-5H-pyridopyrroloisoquinolines (Azaellipticines)

Whereas thermal cyclization of 1-(5,8-dimethyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-1H-v-triazolopyridine affords 6,11-dimethyl-5H-pyridopyrroloisoquinolin-10(9H)-one which cannot be chlorinated to the corresponding chloro derivativ