73323-90-7

Usage

Chemical Class

2-(2,5-dioxopyrrolidin-1-yl)propanoic acid belongs to the class of organic compounds known as alpha amino acids and derivatives.

Molecular Weight

The molecular weight of 2-(2,5-dioxopyrrolidin-1-yl)propanoic acid is 189.18 g/mol.

Physical Appearance

2-(2,5-dioxopyrrolidin-1-yl)propanoic acid is a white crystalline powder.

Derivative of Proline

2-(2,5-dioxopyrrolidin-1-yl)propanoic acid is a derivative of proline, an important amino acid involved in the synthesis of proteins.

Pharmaceutical Research

2-(2,5-dioxopyrrolidin-1-yl)propanoic acid is used in pharmaceutical research as a building block for the synthesis of peptide-based pharmaceuticals.

Chiral Resolving Agent

2-(2,5-dioxopyrrolidin-1-yl)propanoic acid is used as a chiral resolving agent in chromatography.

Industrial Applications

2-(2,5-dioxopyrrolidin-1-yl)propanoic acid is used in the production of drugs and agricultural chemicals.

Therapeutic Benefits

The compound has been researched for its potential therapeutic benefits in the treatment of cancer and viral infections.

Upstream product

• 37142-06-6 (R)-2-(2,5-Dioxo-pyrrolidin-1-yl)-propionaldehyde 
• 108-30-5 succinic acid anhydride 
• 338-69-2 D-Alanine 
• 302-72-7 rac-Ala-OH 
• 53531-15-0 2-(2,5-Dioxo-pyrrolidin-1-yl)-propionaldehyde 
• 2372-96-5 N-vinylsuccinimide 

Downstream Products

• 108159-79-1 4-(2,5-Dioxo-pyrrolidin-1-yl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-pentanoic acid phenylamide 
• 108159-81-5 1-[1-Methyl-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-pyrrolidine-2,5-dione 

Relevant academic research and scientific papers

Design, Synthesis, and Anticonvulsant Activity of New Hybrid Compounds Derived from 2-(2,5-Dioxopyrrolidin-1-yl)propanamides and 2-(2,5-Dioxopyrrolidin-1-yl)butanamides

The library of 27 new 1-(4-phenylpiperazin-1-yl)- or 1-(morpholin-4-yl)-(2,5-dioxopyrrolidin-1-yl)propanamides and (2,5-dioxopyrrolidin-1-yl)butanamides as potential new hybrid anticonvulsant agents was synthesized. These hybrid molecules join the chemica

Design, synthesis and anticonvulsant activity of new hybrid compounds derived from N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and -butanamides

The focused library of 21 new N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide, 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)propanamide, and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives as potential new hybrid anticonvulsant agents was synthesized. These h

Solid phase-solid state synthesis of N-alkyl imides from anhydrides

Preparation of N-alkyl imides from anhydrides is developed on polymer support in solid state assisted by microwave for the first time.

Photoreactions of Succinimides with an N-Acyl Group in the Side Chain. Synthesis and Stereochemistry of Tricyclic Pyrrolopyrazine Ring Systems

Photocyclization of succinimides with an N-acyl group in the side chain gave bi- and tricyclic pyrrolopyrazines, some of which were converted to tricyclic amines by reduction.The stereochemistry of pyrrolopyrazine derivatives is discussed on the basis of the results of X-ray analysis and carbon-13 nuclear magnetic resonance spectroscopy.Keywords - succinimide; photocyclization; pyrrolo-pyrazine; hydrogen abstraction; X-ray analysis; 13C-NMR spectrum; tricyclic diamine

Asymmetric Hydroformylation and Hydrocarboxylation of Enamides. Synthesis of Alanine and Proline

Carbonyltris(triphenylphosphine)hydridorhodium (1) catalyzed the hydroformylation of N-vinylimides in the presence of optically active 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane (DIOP) or 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(5H-dibenzophospholyl)butane (DIPHOL) to afford optically active α-amido aldehydes.Linear disubstituted N-vinylimides or -amides reacted very sluggishly, while the cyclic N-acyl-2-pyrroline (19) was very reactive.In the unsubstituted N-vinylimides moderate (20-40percent ee) asymmetric induction was observed.The optically active α-amido aldehydes were readily converted to the corresponding α-amino acids.Asymmetric hydrocarboxylation of the same substrates in the presence of bis(triphenylphosphine)palladium chloride (2) produced α-amido esters in low optical purity.