2372-96-5

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 23, p. 672, 1958 DOI: 10.1021/jo01099a008

InChI:InChI=1/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h2H,1,3-4H2

Upstream product

• 123-56-8 Succinimide 
• 74-86-2 acetylene 
• 28833-81-0 2-(2,5-dioxopyrrolidin-1-yl)ethyl acetate 
• 18190-44-8 1-(2-Hydroxy-ethyl)-pyrrolidine-2,5-dione 
• 108-05-4 vinyl acetate 

Downstream Products

• 100525-99-3 N-(1-cyclohexylamino-ethyl)-succinimide 
• 36743-55-2 2,3-Dihydro-2-(1-succinimidoyl)-1,4,5-oxathiazin-4,4-dioxid 
• 22237-70-3 N-Vinyl-N'-benzyl-succinamid 
• 4297-70-5 N-Vinyl-N'-aminosuccinamid 
• 91-20-3 naphthalene 
• 141171-91-7 1-<1-(1-naphthyl)ethenyl>succinimide 
• 141171-97-3 (E)-1-<2-(1-naphthyl)ethenyl>succinimide 
• 141172-03-4 1-<1-(3-cyanophenyl)ethenyl>succinimide 
• 141172-04-5 (E)-2-<1-(3-cyanophenyl)ethenyl>succinimide 
• 95607-03-7 1-(E)-cinnamylpyrrolidine-2,5-dione 
• 73323-90-7 (R)-2-(2,5-Dioxo-pyrrolidin-1-yl)-propionic acid 

Relevant academic research and scientific papers

Dynamic kinetic asymmetric [3 + 2] annulation reactions of aminocyclopropanes

We report the first example of a dynamic kinetic asymmetric [3 + 2] annulation reaction of aminocyclopropanes with both enol ethers and aldehydes. Using a Cu catalyst and a commercially available bisoxazoline ligand, cyclopentyl- and tetrahydrofurylamines were obtained in 69-99% yield and up to a 98:2 enantiomeric ratio using the same reaction conditions. The method gives access to important enantio-enriched nitrogen building blocks for the synthesis of bioactive compounds.

Synthesis of aminocyclobutanes by iron-catalyzed [2+2] cycloaddition

Fab Four: An iron-catalyzed [2+2] cycloaddition furnishes aminocyclobutanes with a broad range of substituents in excellent yields and diastereoselectivities. The products can be obtained on a gram scale and can be further converted to β-peptide derivatives in a few steps. Furthermore, a [4+2] cycloaddition between an aminocyclobutane and an olefin leads to the corresponding cyclohexylamines. Copyright

Process for production of cyclic N-vinyl carboxylic acid amide

There is provided a process for producing a cyclic N-vinyl carboxylic acid amide stably in safety and low cost, using, as starting raw materials, a cyclic carboxylic acid ester and monoethanolamine both available inexpensively and easily. The process comprises subjecting a cyclic carboxylic acid ester and monoethanolamine to an intermolecular dehydration reaction (a first-step reaction) in a liquid phase to produce a cyclic N-(2-hydroxyethyl) carboxylic acid amide and then subjecting the cyclic N-(2-hydroxyethyl) carboxylic acid amide to an intramolecular dehydration reaction (a second-step reaction) in a gas phase in the presence of an oxide catalyst containing an alkali metal element and/or an alkaline earth metal element and silicon, to produce a cyclic N-vinyl carboxylic acid amide.