7335-01-5

Basic information

• Product Name: Piperidine, 1-hexyl-
• Synonyms: N-(1-hexyl)piperidine;1-hexyl-piperidine;N-hexylpiperidine;1-C6H13C5H10N;N-n-hexylpiperidine;hexylpiperidine;Piperidine,1-hexyl;Piperidine, 1-hexyl-
• CAS NO: 7335-01-5
• Molecular Formula: C11H23N
• Molecular Weight: 169.31
• Mol File: 7335-01-5.mol

Chemical Properties

• Boiling Point: 219.2°C
• Density: 0.8292
• Refractive Index: 1.4522
• CAS DataBase Reference: Piperidine, 1-hexyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-hexyl-(7335-01-5)
• EPA Substance Registry System: Piperidine, 1-hexyl-(7335-01-5)

Safety Data

• Hazardous Substances Data: 7335-01-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 45, p. 3370, 1980 DOI: 10.1021/jo01304a053

Upstream product

• 110-89-4 piperidine 
• 109-67-1 1-penten 
• 201230-82-2 carbon monoxide 
• 41495-45-8 1-Pentyl-1-hexylamine 
• 1849-29-2 1,1,1-trideuteromethanol 
• 1215074-88-6 1-n-hexyl-1-methylpiperidin-1-ium bromide 
• 766-09-6 1-ethyl-piperidine 
• 646-04-8 (E)-pent-2-ene 

Downstream Products

• 6311-92-8 3-n-hexylpyridine 
• 110-89-4 piperidine 
• 10324-58-0 1-pentylpiperidine 
• 41495-45-8 1-Pentyl-1-hexylamine 
• 143-16-8 dihexylamine 
• 2050-92-2 Di-n-amylamine 
• 109-66-0 pentane 

Relevant articles and documents

Degradation of Organic Cations under Alkaline Conditions

Understanding the degradation mechanisms of organic cations under basic conditions is extremely important for the development of durable alkaline energy conversion devices. Cations are key functional groups in alkaline anion exchange membranes (AAEMs), and AAEMs are critical components to conduct hydroxide anions in alkaline fuel cells. Previously, we have established a standard protocol to evaluate cation alkaline stability within KOH/CD3OH solution at 80 °C. Herein, we are using the protocol to compare 26 model compounds, including benzylammonium, tetraalkylammonium, spirocyclicammonium, imidazolium, benzimidazolium, triazolium, pyridinium, guanidinium, and phosphonium cations. The goal is not only to evaluate their degradation rate, but also to identify their degradation pathways and lead to the advancement of cations with improved alkaline stabilities.

Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction

We report here that C-C coupling in tertiary amines for the synthesis of long chain and hindered amines might be efficiently performed over Pt and Pd catalysts. The mechanism study confirms similarity with the Guerbet reaction through dehydrogenation of the alkyl group and subsequent attack of the α-carbon atom by an alkyl group of another molecule. Finally, secondary amines and tertiary amines with longer alkyl chains are formed.

Highly selective hydroaminomethylation of internal alkenes to give linear amines

The application of phenoxa-phosphino-modified Xantphos-type ligands (1-9) in the rhodium-catalyzed hydroaminomethylation of internal olefins to give linear amines is reported. Excellent chemo- and regioselectivities have been obtained through the use of 0.1 mol % [Rh(cod)2]BF4/0.4 mol% xantphenoxaphos (1), providing a practical and environmentally attractive synthetic route for the preparation of amines from internal alkenes. For the first time, both functionalized internal olefins and mixtures of internal and terminal olefins have been converted highly selectively into linear amines. Investigations of the effects of the calculated natural bite angles of ligands on hydroaminomethylation shows that the regioselectivity for the linear product follows a similar trend to that seen in the hydroformylation of internal alkenes with the aid of these ligands. Hydroaminomethylation and each of its individual steps were monitored by high-pressure infrared spectroscopy. The results suggest that hydroaminomethylations take place by a sequential isomerization/hydroformylation/amination/hydrogenation pathway.

Amines made easily: A highly selective hydroaminomethylation of olefins

A highly chemo- and regioselective hydroaminomethylation of simple as well as functionalized α-olefins using a cationic rhodium precatalyst together with Xantphos as ligand is reported. Studies of the influence of ligands and reaction conditions led to an unprecedented selective hydroaminomethylation procedure. The novel procedure constitutes an economically attractive and environmentally favorable synthesis of secondary and tertiary aliphatic amines.

Hydrogenolysis of nitrogen-containing compounds on cobalt-molybdenium catalyst

Hydrogenolysis of N-(1-hexyl)piperidine, N-(1-pentyl)piperidine and 1-pentyl-1-hexylamine on sulphidized CoO-MoO3 catalysts has been investigated.The primary reaction in the hydrogenolysis is the cleavage of the bond between the nitrogen atom and the methylene group of the alkyl substituent or of the methylene ring.Alkylation and transalkylation reactions on the nitrogen play also a role.