79832-27-2

Upstream product

• 79832-10-3 1-(4,5-dimethoxy-2-nitrobenzyl)-3,4-dihydro-6,7,8-trimethoxyisoquinoline 
• 74-88-4 methyl iodide 
• 54-04-6 mescaline 
• 79831-93-9 4,5-dimethoxy-2-nitro-N-(3,4,5-trimethoxyphenethyl)phenylacetamide 
• 53602-52-1 4,5-dimethoxy-2-nitrophenylacetic acid chloride 
• 73357-18-3 (4,5-dimethoxy-2-nitrophenyl)acetic acid 

Downstream Products

• 549-28-0 protostephanine 
• 20824-18-4 protostephanone 
• 79832-06-7 1-(4,5-dimethoxy-2-nitrobenzyl)-1,2,3,4-tetrahydro-6,7,8-trimethoxy-2-methylisoquinoline 
• 79832-04-5 4,5-Dimethoxy-2-(6,7,8-trimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenylamine 

Relevant academic research and scientific papers

Synthesis along Biosynthetic Pathways. Part 2. Synthesis of Protostephanine

The dienone protostephanone (3) is synthesised by phenol coupling or by Pschorr cyclisation from readily prepared tetrahydroisoquinolines, and the corresponding dienols (17) and (18) are converted by rearrangement, fragmentation, and reduction into protostephanine (4).This sequence mimics the natural pathway to the alkaloid.