73366-01-5

Basic information

• Product Name: Naphthalene,1-(3,4-dimethoxyphenyl)-1,2- dihydro-6,7-dimethoxy-2,3-dimethyl-,(1S,- 2R)-
• CAS NO: 73366-01-5
• Molecular Weight: 354.446
• Mol File: 73366-01-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Naphthalene,1-(3,4-dimethoxyphenyl)-1,2- dihydro-6,7-dimethoxy-2,3-dimethyl-,(1S,- 2R)- (CAS DataBase Reference)
• NIST Chemistry Reference: Naphthalene,1-(3,4-dimethoxyphenyl)-1,2- dihydro-6,7-dimethoxy-2,3-dimethyl-,(1S,- 2R)- (73366-01-5)
• EPA Substance Registry System: Naphthalene,1-(3,4-dimethoxyphenyl)-1,2- dihydro-6,7-dimethoxy-2,3-dimethyl-,(1S,- 2R)- (73366-01-5)

Safety Data

• Hazardous Substances Data: 73366-01-5(Hazardous Substances Data)

Upstream product

• 98333-30-3 5,5-bis-(3,4-dimethoxy-phenyl)-3,4-dimethyl-dihydro-furan-2-one 
• 74084-26-7 3,3',4,4'-tetramethoxybenzhydrole 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 4131-03-7 bis(3,4-dimethoxyphenyl)methanone 

Downstream Products

• 521-54-0 (±)-isogalbulin 
• 521-54-0 (±)-galbulin 
• 6399-14-0 4α-(3,4-dimethoxyphenyl)-2α,3β-dimethyl-6,7-dimethoxy-1-tetralone 

Relevant articles and documents

Bioinspired total synthesis of tetrahydrofuran lignans by tandem nucleophilic addition/redox isomerization/oxidative coupling and cycloetherification reactions as key steps

A very short three-step approach to trans,trans,trans-2,5-diaryl-3,4-dimethyltetrahydrofuran lignans is reported. The carbon skeleton is assembled in a single step based on an unprecedented tandem reaction consisting of 1,2-addition of aryllithium reagents to α,β-unsaturated aldehydes, ruthenium-catalyzed redox isomerization of the resulting alkoxides to enolates and their dimerization triggered by single electron oxidation. The resulting 2,3-dialkyl-1,4-diketones form with moderate to good d/l-diastereoselectivity and are transformed to the target tetrahydrofuran lignans by reduction and diastereoselective cycloetherification.

Total synthesis of cyclogalgravin and its dicarboxyl analog using sc(otf)3-mediated highly diastereoselective ring expansion of 1-(arylhydroxymethyl)cyclopropanecarboxylates

The total synthesis of cyclogalgravin and its dicarboxyl analog was achieved by using the SmI2-promoted Reformatsky type reaction and Sc(OTf)3-mediated diastereoselective ring expansion as key steps.

Synthesis of magnoshinin and cyclogalgravin: Modified stobbe condensation reaction

The development of new methods for lignan synthesis is reported. A recently reported method for the preparation of 1-aryl-1,2-dihydronaphthalenes is exploited to prepare magnoshinin, a naturally occurring lignan, and cyclogalgravin (3,4-dehydrogalbulin), a derivative of a natural lignan.