733734-61-7 Usage
Uses
Used in Pharmaceutical Industry:
Benzenesulfonamide, 2-bromo-4,5-dimethoxy-N-[3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]-4-(trifluoromethyl)phenyl]is used as a high-affinity antagonist for the urotensin-II (UT) receptors in human, mouse, and rat species. Its high affinity towards these receptors makes it a promising candidate for the development of drugs targeting UT receptors, which play a crucial role in various physiological processes and diseases.
Used in Cardiovascular Research:
In the field of cardiovascular research, Benzenesulfonamide, 2-bromo-4,5-dimethoxy-N-[3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]-4-(trifluoromethyl)phenyl]can be employed as a research tool to study the role of UT receptors in cardiovascular diseases. By modulating the activity of these receptors, it can help researchers understand the underlying mechanisms and develop potential therapeutic strategies for treating related conditions.
Used in Drug Development:
Benzenesulfonamide, 2-bromo-4,5-dimethoxy-N-[3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]-4-(trifluoromethyl)phenyl]can be utilized in drug development for the treatment of various diseases associated with the urotensin-II (UT) receptors. Its high affinity towards these receptors allows for the design and synthesis of novel drugs that can effectively target and modulate their activity, potentially leading to improved therapeutic outcomes for patients.
Used in Drug Screening:
In the process of drug screening, Benzenesulfonamide, 2-bromo-4,5-dimethoxy-N-[3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]-4-(trifluoromethyl)phenyl]can serve as a reference compound to evaluate the potency and selectivity of other potential UT receptor antagonists. This can help in the identification of more effective and safer drug candidates for further development and clinical testing.
Check Digit Verification of cas no
The CAS Registry Mumber 733734-61-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,3,3,7,3 and 4 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 733734-61:
(8*7)+(7*3)+(6*3)+(5*7)+(4*3)+(3*4)+(2*6)+(1*1)=167
167 % 10 = 7
So 733734-61-7 is a valid CAS Registry Number.
733734-61-7Relevant academic research and scientific papers
Deconstruction of sulfonamide inhibitors of the urotensin receptor (UT) and design and synthesis of benzylamine and benzylsulfone antagonists
Taylor, Steven J.,Soleymanzadeh, Fariba,Muegge, Ingo,Akiba, Isamu,Taki, Naoyuki,Ueda, Saisoku,Mainolfi, Elizabeth,Eldrup, Anne B.
supporting information, p. 2177 - 2180 (2013/04/24)
Potent small molecule antagonists of the urotensin receptor are described. These inhibitors were derived via systematically deconstructing a literature inhibitor to understand the basic pharmacophore and key molecular features required to inhibit the prot
