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Usage

Uses

Used in Organic Synthesis:
Tert-butyl 4-oxo-3-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate is utilized as a key intermediate in the preparation of various pharmaceuticals and agrochemicals. Its unique structure and reactivity allow for the creation of a wide range of molecules with potential applications in these fields.
Used in Medicinal Chemistry and Drug Discovery:
tert-butyl 4-oxo-3-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate is also employed as a building block in medicinal chemistry and drug discovery. Its interesting pharmacological properties make it a promising candidate for the development of new drugs and therapeutic agents.
Used in Chemical Compound Synthesis:
Due to its versatile reactivity, tert-butyl 4-oxo-3-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate is used as a starting material for the synthesis of a wide range of chemical compounds. Its stability and unique functional groups contribute to the formation of diverse molecular structures with potential applications in various industries.

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 407-25-0 trifluoroacetic anhydride 
• 217807-98-2 4-morpholin-4-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid ter-tbutyl ester 

Downstream Products

• 853784-19-7 3-trifluoromethyl-4,5,6,7-tetrahydro-isoxazolo[4,3-c]pyridine 
• 794451-94-8 1-methyl-3-trifluoromethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine 
• 853784-42-6 2-methyl-3-trifluoromethyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine 

Relevant academic research and scientific papers

BICYCLIC BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION

The present invention relates to certain bicyclic bis-heteroaryl compounds of Formula (I), pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and

A novel series of positive modulators of the AMPA receptor: Structure-based lead optimization

Starting from lead compound 1, we demonstrate how X-ray structural data can be used to understand SAR and expediently optimize bioavailability in a novel series of AMPA receptor modulators, furnishing 5 with improved bioavailability and robust in vivo activity.

COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE

Compounds of formula (I), and salts and solvates thereof are provided: Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.