73377-99-8Relevant academic research and scientific papers
Copper-catalyzed three-component reaction of: N-heteroaryl aldehydes, nitriles, and water
Bao, Hanyang,Zhou, Bingwei,Jin, Hongwei,Liu, Yunkui
, p. 5021 - 5028 (2019)
An efficient and straightforward method for the synthesis of N-heteroaroyl imides has been successfully developed involving a copper-catalyzed radical-triggered three-component reaction of N-heteroaryl aldehydes, nitriles, and water. Mechanistic studies indicate that the reaction may undergo a radical-triggered Ritter-type reaction in which water serves as the oxygen source for the formation of the C-O bond. The reaction has advantages such as a broad substrate scope for the N-heteroaryl aldehydes, atom economy, and simple operation.
