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73458-39-6

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73458-39-6 Usage

Description

5-NITRO-BENZOTHIAZOL-2-YLAMINE is a chemical compound characterized by the molecular formula C7H5N3O2S. It is a yellow solid with a melting point of 215-219 degrees Celsius and exhibits insolubility in water. 5-NITRO-BENZOTHIAZOL-2-YLAMINE is recognized for its diverse potential applications, including its use as a reagent in organic synthesis and pharmaceutical research, as well as its antimicrobial, antiparasitic, anticancer, antifungal, and antioxidant properties.

Uses

Used in Organic Synthesis:
5-NITRO-BENZOTHIAZOL-2-YLAMINE is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions, contributing to the creation of new compounds and materials.
Used in Pharmaceutical Research:
In pharmaceutical research, 5-NITRO-BENZOTHIAZOL-2-YLAMINE is utilized as a reagent to aid in the development and testing of new drugs, leveraging its chemical properties to enhance drug discovery processes.
Used in Antimicrobial Applications:
5-NITRO-BENZOTHIAZOL-2-YLAMINE is used as an antimicrobial agent for its potential to combat microbial infections, providing a means to control or eliminate harmful microorganisms.
Used in Antiparasitic Applications:
As an antiparasitic agent, 5-NITRO-BENZOTHIAZOL-2-YLAMINE is employed to treat infections caused by parasites, offering a potential therapeutic solution for parasitic diseases.
Used in Anticancer Applications:
5-NITRO-BENZOTHIAZOL-2-YLAMINE is studied for its potential as an anticancer agent, with research exploring its ability to inhibit the growth and proliferation of cancer cells, contributing to cancer treatment strategies.
Used in Antifungal Applications:
In antifungal applications, 5-NITRO-BENZOTHIAZOL-2-YLAMINE is used to prevent or treat fungal infections, providing a means to combat fungi that can cause diseases in humans and other organisms.
Used in Antioxidant Applications:
5-NITRO-BENZOTHIAZOL-2-YLAMINE is also recognized for its antioxidant properties, which can be utilized in various industries to prevent oxidative damage and support overall health and preservation of materials.

Check Digit Verification of cas no

The CAS Registry Mumber 73458-39-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,4,5 and 8 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 73458-39:
(7*7)+(6*3)+(5*4)+(4*5)+(3*8)+(2*3)+(1*9)=146
146 % 10 = 6
So 73458-39-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H5N3O2S/c8-7-9-5-3-4(10(11)12)1-2-6(5)13-7/h1-3H,(H2,8,9)

73458-39-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-nitro-1,3-benzothiazol-2-amine

1.2 Other means of identification

Product number -
Other names 2-amino-5-nitrobenzothiazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:73458-39-6 SDS

73458-39-6Relevant articles and documents

Photochemistry of 5-nitro-1,2-benzisothiazole derivatives: effects of substituents, solvents and excitation wavelength

Tanikawa, Hiroharu,Ishii, Kazuhiro,Kubota, Shun,Yagai, Shiki,Kitamura, Akihide,Karatsu, Takashi

, p. 3444 - 3448 (2008)

3-R-5-Nitro-1,2-benzisothiazole derivatives (1, R = substituents) in solution, undergo photochemical isomerization to produce 2-R-5-nitro-1,2-benzothiazole derivatives. Here, generalizations and limitations by the substituent, solvent, and excitation wave

Synthesis and anticonvulsant evaluation of indoline derivatives of functionalized aryloxadiazole amine and benzothiazole acetamide

Akhtar, Md Jawaid,Debnath, Biplab,Grover, Gourav,Nath, Rajarshi,Pathania, Shelly,Shahar Yar, M.

, (2020/12/25)

A series of N-(substituted benzothiazole-2-yl)-2-(2,3-dioxoindolin-1-yl)acetamide (4a-i) and substituted-[3-((5-phenyl-1,3,4-oxadiazole-2-yl)imino)indolene-2-one] (5a-f) were designed, synthesized fulfilling the structural requirement of pharmacophore and evaluated for anticonvulsant activities using maximal electroshock test (MES), subcutaneous pentylenetetrazole (scPTZ) seizures and neurotoxicity by motor impairment model in mice. The most active compoundN-(5-chlorobenzo[d]thiazol-2-yl)-2-(2,3-dioxoindolin-1-yl)acetamide (4a) has shown significant anticonvulsant activity against both MES and scPTZ screens and emerged as most effective anticonvulsant compound with median dose of 35.7 mg/kg (MES ED50), 88.15 mg/kg (scPTZ ED50) and toxic dose (TD50) was found to be > 500mg/kg. In silico studies including molecular docking study was carried to establish the molecular interaction of potent compound (4a) in both Na+ channel and GABAA receptors. The prediction of pharmacokinetic parameters and distance mapping of compounds were also performed to establish the drug likeness property.

ANTIBIOTIC COMPOUNDS, PHARMACEUTICAL FORMULATIONS THEREOF AND METHODS AND USES THEREFOR

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Page/Page column 224; 284, (2017/06/30)

The present invention relates to compounds of formula (I) wherein G1 to G8 are as defined herein. The compounds are PK inhibitors and as such represent a new approach to treating pathogenic infections, including multidrug resistant pathogens. Disclosed herein are the compounds of formula (I), pharmaceutical compositions comprising the compounds of formula (I) and their use in the treatment of antimicrobial infection. (Formula (1))

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