73458-39-6

Basic information

• Product Name: 5-NITRO-BENZOTHIAZOL-2-YLAMINE
• Synonyms: SALOR-INT L133531-1EA;2-AMINO-5-NITROBENZOTHIAZOLE;5-NITRO-BENZOTHIAZOL-2-YLAMINE;2-Benzothiazolamine,5-nitro-(9CI);5-Nitro-1,3-benzothiazol-2-amine;2-AMINO-5-NITROBENZOTHIZOLE;2-BenzothiazolaMine,5-nitro-;5-Nitrobenzo[d]thiazol-2-aMine
• CAS NO: 73458-39-6
• Molecular Formula: C₇H₅N₃O₂S
• Molecular Weight: 195.2
• Product Categories: BENZOTHIAZOLE
• Mol File: 73458-39-6.mol
• Article Data: 22

Chemical Properties

• Melting Point: 308-309 °C (decomp)
• Boiling Point: 411.7°C at 760 mmHg
• Flash Point: 202.8°C
• Appearance: /
• Density: 1.621g/cm³
• Vapor Pressure: 5.48E-07mmHg at 25°C
• Refractive Index: 1.797
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.22±0.10(Predicted)
• CAS DataBase Reference: 5-NITRO-BENZOTHIAZOL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-NITRO-BENZOTHIAZOL-2-YLAMINE(73458-39-6)
• EPA Substance Registry System: 5-NITRO-BENZOTHIAZOL-2-YLAMINE(73458-39-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 73458-39-6(Hazardous Substances Data)

Usage

Description

5-NITRO-BENZOTHIAZOL-2-YLAMINE is a chemical compound characterized by the molecular formula C7H5N3O2S. It is a yellow solid with a melting point of 215-219 degrees Celsius and exhibits insolubility in water. 5-NITRO-BENZOTHIAZOL-2-YLAMINE is recognized for its diverse potential applications, including its use as a reagent in organic synthesis and pharmaceutical research, as well as its antimicrobial, antiparasitic, anticancer, antifungal, and antioxidant properties.

Uses

Used in Organic Synthesis:
5-NITRO-BENZOTHIAZOL-2-YLAMINE is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions, contributing to the creation of new compounds and materials.
Used in Pharmaceutical Research:
In pharmaceutical research, 5-NITRO-BENZOTHIAZOL-2-YLAMINE is utilized as a reagent to aid in the development and testing of new drugs, leveraging its chemical properties to enhance drug discovery processes.
Used in Antimicrobial Applications:
5-NITRO-BENZOTHIAZOL-2-YLAMINE is used as an antimicrobial agent for its potential to combat microbial infections, providing a means to control or eliminate harmful microorganisms.
Used in Antiparasitic Applications:
As an antiparasitic agent, 5-NITRO-BENZOTHIAZOL-2-YLAMINE is employed to treat infections caused by parasites, offering a potential therapeutic solution for parasitic diseases.
Used in Anticancer Applications:
5-NITRO-BENZOTHIAZOL-2-YLAMINE is studied for its potential as an anticancer agent, with research exploring its ability to inhibit the growth and proliferation of cancer cells, contributing to cancer treatment strategies.
Used in Antifungal Applications:
In antifungal applications, 5-NITRO-BENZOTHIAZOL-2-YLAMINE is used to prevent or treat fungal infections, providing a means to combat fungi that can cause diseases in humans and other organisms.
Used in Antioxidant Applications:
5-NITRO-BENZOTHIAZOL-2-YLAMINE is also recognized for its antioxidant properties, which can be utilized in various industries to prevent oxidative damage and support overall health and preservation of materials.

InChI:InChI=1/C7H5N3O2S/c8-7-9-5-3-4(10(11)12)1-2-6(5)13-7/h1-3H,(H2,8,9)

Upstream product

• 1594-56-5 2,4-dinitro-phenyl thiocyanate 
• 709-72-8 3-nitrophenylthiourea 
• 84387-89-3 3-amino-5-nitro-1,2-benzisothiazole 
• 99-09-2 3-nitro-aniline 
• 2942-07-6 5-nitrobenzothiazole 
• 3425-46-5 potassium selenocyanate 
• 333-20-0 potassium thioacyanate 
• 1147550-11-5 ammonium thiocyanate 
• 17356-08-0 thiourea 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 2217-55-2 bis(2,4-dinitrophenyl) disulphide 
• 333741-82-5 1-benzoyl-3-(2-fluoro-5-nitrophenyl)thiourea 
• 341036-37-1 N-((2-chloro-5-nitrophenyl)carbamothioyl)benzamide 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 

Downstream Products

• 100856-56-2 2-benzoylamino-5-nitro-1,3-benzothiazole 
• 1240167-94-5 C₂₃H₁₇N₃O₃S 
• 1448530-43-5 3-(5-nitrobenzo[d]thiazol-2-yl)-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one 
• 1448530-56-0 (E)-3-(5-nitrobenzo[d]thiazol-2-yl)-2-styryl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one 
• 1315085-60-9 C₂₁H₁₆N₁₀O₅S₃ 
• 3507-44-6 2-bromo-5-nitrobenzo[d]thiazole 
• 1357251-54-7 N-(5-nitrobenzo[d]thiazol-2-yl)-2-(4-phenylpiperazin-1-yl)acetamide 
• 1240167-86-5 2,3-bis(4-methoxyphenyl)-6-nitroimidazo[2,1-b][1,3]benzothiazole 
• 1223564-40-6 1-(5-nitrobenzo[d]thiazol-2-yl)-3-(4-nitrobenzoyl) thiourea 
• 1223564-48-4 1-benzoyl-3-(5-nitrobenzo[d]thiazol-2-yl) thiourea 
• 659743-51-8 1-(2-aminobenzothiazol-5-yl)-3-benzoylthiourea 
• 939795-82-1 C₁₉H₂₁N₄SF 
• 939795-81-0 C₁₉H₂₂N₄S 
• 939795-72-9 C₁₉H₁₉N₄O₂SF 

Relevant articles and documents

Photochemistry of 5-nitro-1,2-benzisothiazole derivatives: effects of substituents, solvents and excitation wavelength

3-R-5-Nitro-1,2-benzisothiazole derivatives (1, R = substituents) in solution, undergo photochemical isomerization to produce 2-R-5-nitro-1,2-benzothiazole derivatives. Here, generalizations and limitations by the substituent, solvent, and excitation wave

Synthesis and anticonvulsant evaluation of indoline derivatives of functionalized aryloxadiazole amine and benzothiazole acetamide

A series of N-(substituted benzothiazole-2-yl)-2-(2,3-dioxoindolin-1-yl)acetamide (4a-i) and substituted-[3-((5-phenyl-1,3,4-oxadiazole-2-yl)imino)indolene-2-one] (5a-f) were designed, synthesized fulfilling the structural requirement of pharmacophore and evaluated for anticonvulsant activities using maximal electroshock test (MES), subcutaneous pentylenetetrazole (scPTZ) seizures and neurotoxicity by motor impairment model in mice. The most active compoundN-(5-chlorobenzo[d]thiazol-2-yl)-2-(2,3-dioxoindolin-1-yl)acetamide (4a) has shown significant anticonvulsant activity against both MES and scPTZ screens and emerged as most effective anticonvulsant compound with median dose of 35.7 mg/kg (MES ED50), 88.15 mg/kg (scPTZ ED50) and toxic dose (TD50) was found to be > 500mg/kg. In silico studies including molecular docking study was carried to establish the molecular interaction of potent compound (4a) in both Na+ channel and GABAA receptors. The prediction of pharmacokinetic parameters and distance mapping of compounds were also performed to establish the drug likeness property.

ANTIBIOTIC COMPOUNDS, PHARMACEUTICAL FORMULATIONS THEREOF AND METHODS AND USES THEREFOR

The present invention relates to compounds of formula (I) wherein G1 to G8 are as defined herein. The compounds are PK inhibitors and as such represent a new approach to treating pathogenic infections, including multidrug resistant pathogens. Disclosed herein are the compounds of formula (I), pharmaceutical compositions comprising the compounds of formula (I) and their use in the treatment of antimicrobial infection. (Formula (1))