5180-75-6

Usage

Uses

Used in Pharmaceutical and Medical Research:
4-[(ETHOXYCARBONYL)AMINO]BENZOIC ACID is used as a research compound for its potential therapeutic properties, contributing to the advancement of pharmaceutical and medical research.
Used in Organic Synthesis:
4-[(ETHOXYCARBONYL)AMINO]BENZOIC ACID is used as a key intermediate in organic synthesis, facilitating the creation of a variety of chemical compounds.
Used as a Starting Material for Pharmaceutical Production:
4-[(ETHOXYCARBONYL)AMINO]BENZOIC ACID is utilized as a starting material in the production of various pharmaceuticals, playing a crucial role in the development of new drugs.
Used in Anti-inflammatory and Analgesic Drug Development:
4-[(ETHOXYCARBONYL)AMINO]BENZOIC ACID is used as a valuable tool in the development of new anti-inflammatory and analgesic drugs, due to its studied effects in these areas.

InChI:InChI=1/C10H11NO4/c1-2-15-10(14)11-8-5-3-7(4-6-8)9(12)13/h3-6H,2H2,1H3,(H,11,14)(H,12,13)

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 150-13-0 4-amino-benzoic acid 
• 1609-47-8 diethyl dicarbonate 
• 1425322-22-0 (ethoxycarbonyloxy)carbonimidoyl dicyanide 
• 1425322-24-2 ethyl 2-oxopyridin-1(2H)-yl carbonate 
• 59577-40-1 6-chloro-1H-benzo[d][1,2,3]triazol-1-yl ethyl carbonate 
• 1425322-27-5 3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl ethyl carbonate 
• 41844-51-3 ethyl 2-cyano-2-(ethoxycarbonyloxyimino)acetate 
• 22669-27-8 p-aminobenzoic acid hydrochloride 
• 64-17-5 ethanol 
• 3729-21-3 4-isocyanatobenzoic acid chloride 

Downstream Products

• 59443-94-6 3-(4-aminophenyl)-3-oxopropanenitrile 
• 5180-74-5 4-ethoxycarbonylamino-benzoyl chloride 

Relevant academic research and scientific papers

Design and development of novel p-aminobenzoic acid derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer's disease

Based on the quantitative structure-activity relationship (QSAR), some novel p-aminobenzoic acid derivatives as promising cholinesterase enzyme inhibitors were designed, synthesized, characterized and evaluated to enhance learning and memory. The in vitro

Urethane hapten composition and artificial antigen composition, and preparation methods and application thereof

The invention discloses a urethane hapten composition and artificial antigen composition, and preparation methods and application thereof. The urethane artificial antigen composition has molecular structures as shown in a formula (III) and a formula (IV).

Synthesis, analysis, cholinesterase-inhibiting activity and molecular modelling studies of 3-(dialkylamino)-2-hydroxypropyl 4-[(alkoxy-carbonyl)amino]benzoates and their quaternary ammonium salts

Tertiary amines 3-(dialkylamino)-2-hydroxypropyl 4-[(alkoxycarbonyl)amino]benzoates and their quaternary ammonium salts were synthesized. The final step of synthesis of quaternary ammonium salts was carried out by microwave-assisted synthesis. Software-ca

An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors

Sphingosine kinase 1 (SphK1), the enzyme that produces the bioactive sphingolipid metabolite, sphingosine-1-phosphate, is a promising new molecular target for therapeutic intervention in cancer and inflammatory diseases. In view of its importance, the main objective of this work was to find new and more potent inhibitors for this enzyme possessing different structural scaffolds than those of the known inhibitors. Our theoretical and experimental study has allowed us to identify two new structural scaffolds (three new compounds), which could be used as starting structures for the design and then the development of new inhibitors of SphK1. Our study was carried out in different steps: virtual screening, synthesis, bioassays and molecular modelling. From our results, we propose a new dihydrobenzo[b]pyrimido[5,4-f]azepine and two alkyl{3-/4-[1-hydroxy-2-(4-arylpiperazin-1-yl)ethyl]phenyl}carbamates as initial structures for the development of new inhibitors. In addition, our molecular modelling study using QTAIM calculations, allowed us to describe in detail the molecular interactions that stabilize the different Ligand-Receptor complexes. Such analyses indicate that the cationic head of the different compounds must be refined in order to obtain an increase in the binding affinity of these ligands.

Oxime-Based carbonates as useful reagents for both n-protection and peptide coupling

We have demonstrated that oxime-based mixed carbonates are very effective reagents for both N-protection and peptide coupling.

A new access to quinazolines from simple anilines

A new synthetic pathway to quinazolines is described. This new method uses hexamethylenetetramine in TFA and potassium ferricyanide in aqueous ethanolic KOH, starting from simple N-protected anilines. The method affords substituted quinazolines with high

Synthesis of some heterocycle containing urea derivatives and their anti-viral activity

Some new isoindol heterocyclic ureas (6a-6i) have been synthesized using N-aminophthalimide (2) and ethyl N-monosubstituted/ethyl N,N-disubstituted carbamate (5a-5i). All the newly synthesized final compounds have been evaluated for their anti-viral activities against a variety of viruses. The compound (6f) with the methoxy substituent showed reasonably better activity as compared to the standard drugs against all the viruses (cf. Tables 1, 2 and 3). Further, all the products (6a-6i) were found to be active against Vesicular stomatitis virus, Coxsackie virus B4 and Respiratory syncytical virus (cf. Table 2) and the compounds (6h) and (6i) displayed better antiviral activity in comparison to Brivudin and (S)-DHPA (cf. Table 3).

Synthesis and pharmacological evaluation of novel potential ultrashort-acting β-blockers

The basic relationship between chemical structure and pharmacological activity of eight newly developed potential ultrashort-acting β-adrenergic blockers was evaluated. The compounds studied are derivatives of arylcarbonyloxyaminopropanols and were prepar