7347-97-9

Usage

Uses

Used in Pharmaceutical Industry:
2-METHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID is used as a cysteine prodrug for its protective effects against the fungal T-2 toxin. It serves as a precursor to pharmaceuticals used in the treatment of cataracts, where it plays a crucial role in maintaining the transparency of the eye lens and preventing the formation of cataracts.
Used in Chemical Industry:
In the chemical industry, 2-METHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID can be utilized as a building block for the synthesis of various complex organic molecules and pharmaceutical compounds. Its unique structure and functional groups make it a valuable intermediate in the development of new drugs and chemical products.

InChI:InChI=1/C5H9NO2S/c1-3-6-4(2-9-3)5(7)8/h3-4,6H,2H2,1H3,(H,7,8)

Upstream product

• 75-07-0 acetaldehyde 
• 921-01-7 D-cysteine 
• 52-90-4 L-Cysteine 
• 52-89-1 l-cysteine hydrochloride 
• 921-01-7 rac-cysteine 
• 50-00-0 formaldehyd 

Downstream Products

• 107321-69-7 (R)-3-(2-Benzyloxycarbonylamino-acetyl)-2-methyl-thiazolidine-4-carboxylic acid 

Relevant academic research and scientific papers

Synthetic preparation method and application of meyeniin A derivatives

The invention discloses a synthetic preparation method and an application of meyeniin A derivatives (I and II). The synthetic route of the method is as shown in the description. The meyeniin A derivatives are synthetic derivatives (I and II) of meyeniin A. The compounds are a series of artificial analogues synthesized through a two-step chemical reaction with a novel natural alkaloid meyeniin A separated from a medicinal plant maca as a template and precursor cysteine as an initiating raw material. The meyeniin A derivatives are basically structurally characterized by being composed of a hexahydroimidazole[1,5-c] thiazole nuclear parent and a benzyl substituent of different substituents. The different substituents on a side chain substituent determine diversity of the compounds. The synthetic derivatives of meyeniin A are synthesized for the first time and part of the derivatives have potential bioactivity, so that the compounds can be used as lead compounds of anti-tumor drugs, and have certain research value and application prospect.

(+)-Meyeniins A-C, Novel Hexahydroimidazo[1,5-c]thiazole Derivatives from the Tubers of Lepidium meyenii: Complete Structural Elucidation by Biomimetic Synthesis and Racemic Crystallization

(+)-Meyeniins A-C (1-3), a novel class of sulfur-containing hexahydroimidazo[1,5-c]thiazole derivatives, were isolated from the tubers of Lepidium meyenii (maca) cultivated in Lijiang, Yunnan province, China. Guided by their biosynthetic hypothesis, a ste

HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR INHIBITING LIPID ACCUMULATION CONTAINING SAME

The present invention relates to a novel heterocyclic carboxylic acid derivative, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient for inhibiting the accumulation of lipids in the body.

Azafulvenium methides: New extended dipolar systems

The transient 1-azafulvenium methides 24, 26 and 28 generated by thermal extrusion of sulfur dioxide from pyrrolo[1,2-c][1,3]thiazole 2,2-dioxide 20 (R = Me), 22 and 23 undergo sigmatropic [1,8]H shifts and the 1-acyl derivatives 30 electrocyclise to give novel pyrrolo[1,2-c][1,3]oxazines 32. The analogous 1,2-diazafulvenium methide 36 has been intercepted in [8π + 2π] cycloadditions with electron-rich silylated acetylenes to give adducts 37-40. This behaviour is partially explained by Frontier MO theory.

Azafulvenium methides: New extended dipolar systems

The transient 8π 1,7-dipolar azafulvenium methides 5 and 8 undergo sigmatropic [1,8] H shifts and the acyl derivatives 12 electrocyclise to give novel pyrrolooxazines 13; the related diazafulvenium methide 15 can be intercepted in 8π + 2π cycloadditions with silylated acetylenes.

Amino-acid zwitterion equilibria: vibrational and nuclear magnetic resonance studies of methyl-substituted thiazolidine-4-carboxylic acids

Infrared and Raman spectra (4000-100 cm-1) of solid samples of six different methyl substituted thiazolidine products of D-penicillamine and L-cysteine hydrochloride have been observed and assigned, Infrared spectra in D2O solutions have been obtained for comparison in order to study the amino-acid zwitterion equilibria.Proton and 13C nmr spectra for the compounds have also been measured.

2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity

A number of 2-alkyl- and 2-aryl-substituted thiazolidine-4(R)-carboxylic acids were evaluated for their protective effect against hepatotoxic deaths produced in mice by LD90 doses of acetaminophen. 2(RS)-Methyl-(1b),2(RS)-n-propyl-, and 2(RS)-n