735265-97-1

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 118465-82-0 diphenyl 1-(phenylamino)-1-(4-cyanophenyl)methanephosphonate 
• 623-12-1 4-chloromethoxybenzene 
• 1443-80-7 4-cyanophenyl methyl ketone 

Downstream Products

• 735265-98-2 4-[Bromo(4-methoxyphenyl)acetyl]benzonitrile 

Relevant academic research and scientific papers

Method for preparing substituted aryl ketone by ketone arylation (by machine translation)

The invention provides a method, for preparing substituted aryl ketone, by using a nitrogen heterocyclic carbene catalyst, with a saturated nitrogen heterocyclic carbene structure in an oxygen-containing atmosphere at, through α - catalysis of a nitrogen heterocyclic carbene structure, in a nitrogen heterocyclic carbene catalyst with a saturated nitrogen heterocyclic carbene structure under an alkaline condition, in an oxygen-containing atmosphere and can efficiently prepare various substituted, aryl ketones α - under the condition of containing an oxygen. atmosphere. (by machine translation)

Lewis Acid Assisted Electrophilic Fluorine-Catalyzed Pinacol Rearrangement of Hydrobenzoin Substrates: One-Pot Synthesis of (±)-Latifine and (±)-Cherylline

A microwave-irradiated solvent-free pinacol rearrangement of hydrobenzoin substrates catalyzed by a combination of N-fluorobenzenesulfonimide and FeCl3·6H2O was developed. Its selectivity was first investigated by density functional theory (DFT) calculations. Then the functional group tolerance was examined by synthesizing a series of substrates designed based on the insight provided by the DFT calculations. The application of the methodology was demonstrated by the efficient one-pot synthesis of (±)-latifine and (±)-cherylline, both are 4-aryltetrahydroisoquinoline alkaloids isolated from Amaryllidacecae plants.

Inhibitor of cox

A compound of the formula (I): wherein R1 is cycloalkyl, etc; R2 is (lower)alkoxy, etc; R3 is (lower)alkylene, etc; R4 is (lower)alkylene, etc; R5 is hydroxy, etc; X is “O”, “S”, “SO”, or “SO2”; Y is “CH” or “N”; n is 0 or 1; or pharmaceutically acceptable salts thereof, which are useful as a medicament.