862135-55-5

Usage

Uses

Used in Organic Synthesis:
Acetic acid 5,6-dibromo-indan-2-yl ester is used as a reagent in organic synthesis for its ability to participate in various chemical reactions, contributing to the formation of new compounds with desired properties.
Used in Chemical Reactions:
In the chemical industry, Acetic acid 5,6-dibromo-indan-2-yl ester is used as a reagent for its potential to facilitate specific reactions, enabling the production of target molecules or materials with specific applications.

Upstream product

• 4254-29-9 indan-2-ol 
• 4254-31-3 2-acetoxyindane 

Downstream Products

• 862135-56-6 5,6-dibromoindan-2-ol 
• 312753-53-0 5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride 
• 73536-88-6 5-bromo-2-aminoindane 

Relevant academic research and scientific papers

Method for preparing 5,6-diethyl-2,3-dihydro-1H-indene-2-amino hydrochloride

The invention relates to a novel synthesis route of a method for preparing 5,6-diethyl-2,3-dihydro-1H-indene-2-amino hydrochloride. 2-indanol is adopted as a raw material, and 5,6-diethyl-2,3-dihydro-1H-indene-2-amino hydrochloride is synthesized with a high yield through seven steps of an acetylation reaction, a substitution reaction, a coupling reaction, a hydroxyl protection reaction, a substitution reaction, a reduction reaction and a salting reaction. The preparation method of the 5,6-diethyl-2,3-dihydro-1H-indene-2-amino hydrochloride, which is provided by the invention, is a preparationmethod which is high in yield, low in cost, friendly to the environment, easy to operate and applicable to industrialization.

Daucus carota and baker's yeast mediated bio-reduction of prochiral ketones

Stereoselective reduction of prochiral ketones to the corresponding alcohols using biocatalysts has attracted much attention, from the viewpoint of green chemistry. Asymmetric reduction of indanone, tetralone and hydroxyl trimonoterpene ketones to the corresponding enantiomerically pure (S)-alcohols, using Daucus carota plant homogenate and fermented baker's yeast cells, is described. The present study illustrates the broad substrate selectivity of the dehydrogenase enzymes present in the D. carota in the synthesis of a wide range of chiral secondary alcohols of biological importance.

Concise syntheses of 2-aminoindans via indan-2-ol

2-Amino-5,6-dimethoxyindan hydrochloride was synthesized in seven steps and with an overall yield of 48%. Indan-2-ol was converted to 5,6-dibromo-indan-2- ol in three steps by acetylation, electrophilic bromination and deacetylation. Dimethoxylation of 5,6-dibromoindan-2-ol with NaOCH3 in the presence of CuI gave 5,6-dimethoxy-indan-2-ol, which was converted to 2-amino-5,6-dimethoxyindan hydrochloride by azidation, followed by Pd-C catalyzed hydrogenation. Similarly, 2-amino-5-bromoindan was synthesized in five steps and with an overall yield of 50%. Indan-2-ol was converted to 2-aminoindan by azidation followed by Pd-C catalyzed hydrogenation. The reaction of 2-aminoindan with 2.5 equiv Br2 afforded 2-amino-5,6- dibromoindan.