7356-41-4

Basic information

• Product Name: 2,5-DIMETHYLPHENOXYACETIC ACID
• Synonyms: LABOTEST-BB LT00454423;AKOS BC-2697;AKOS BBB/222;2,5-DIMETHYLPHENOXYACETIC ACID;2,5-xylyloxyacetic acid;2,5-Dimethylphenoxyacetic acid, 98+%;Acetic acid, (2,5-dimethylphenoxy)-;Ai3-16548
• CAS NO: 7356-41-4
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2
• EINECS: 230-887-1
• Mol File: 7356-41-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 114-116°C
• Boiling Point: 308.7 °C at 760 mmHg
• Flash Point: 121.1 ºC
• Appearance: /
• Density: 1.146 g/cm³
• Vapor Pressure: 0.00029mmHg at 25°C
• Refractive Index: 1.533
• BRN: 2263621
• CAS DataBase Reference: 2,5-DIMETHYLPHENOXYACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHYLPHENOXYACETIC ACID(7356-41-4)
• EPA Substance Registry System: 2,5-DIMETHYLPHENOXYACETIC ACID(7356-41-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 7356-41-4(Hazardous Substances Data)

Usage

General Description

2,5-DIMETHYLPHENOXYACETIC ACID is a chemical compound with the molecular formula C10H12O3. It is a derivative of acetic acid and contains a phenyl group with two methyl substituents attached to the benzene ring. This chemical is commonly used as a herbicide and plant growth regulator to control the growth of weeds and unwanted plants. It works by interfering with the plant's growth hormones, leading to stunted growth and ultimately death. Additionally, 2,5-DIMETHYLPHENOXYACETIC ACID has applications in the synthesis of other organic compounds and pharmaceuticals. However, it is important to handle this chemical with care as it can be toxic and harmful if not used properly.

InChI:InChI=1/C10H12O3/c1-7-3-4-8(2)9(5-7)13-6-10(11)12/h3-5H,6H2,1-2H3,(H,11,12)

Upstream product

• 95-87-4 2,5-Dimethylphenol 
• 79-11-8 chloroacetic acid 
• 59956-48-8 isobutyl 2-bromoacetate 
• 3926-62-3 sodium monochloroacetic acid 
• 79-08-3 bromoacetic acid 

Downstream Products

• 95450-80-9 (2,5-dimethylphenoxy)acetic acid methyl ester 
• 143189-97-3 2-(2,5-Dimethyl-phenoxy)-1-{4-[2-(2,5-dimethyl-phenoxy)-acetyl]-piperazin-1-yl}-ethanone 
• 148183-91-9 2-(2,5-Dimethyl-phenoxy)-1-morpholin-4-yl-ethanone 

Relevant articles and documents

Gemfibrozil derivatives as activators of soluble guanylyl cyclase – A structure-activity study

Previous studies demonstrated that anti-hyperlipidemic drug gemfibrozil acts as NO- and heme-independent activator of NO receptor soluble guanylyl cyclase. A series of new gemfibrozil derivatives were synthesized and evaluated for sGC activation. The structure-activity relationship study identified the positions in gemfibrozil's scaffold that are detrimental for sGC activation and those that are amendable for optimizing modifications. Compared with gemfibrozil, compounds 7c and 15b were more potent activators of cGMP-forming activity of purified sGC and exhibited enhanced relaxation of preconstricted mouse thoracic aorta rings. These studies established the overall framework needed for futher improvement of sGC activators based on gemfibrozil scaffold.

An efficient synthesis of benzofurans and their application in the preparation of natural products of the genus Calea

The intramolecular cyclization of the β-substituted olefins methyl 2-aryloxy-3-dimethylaminopropenoates 3a-3f catalyzed by Lewis acids leads to a short and novel synthesis of benzofurans 2a-2f. When the olefins 4-dimethylamino-3-aryloxy-3-buten-2-ones 4a-4f were used, the cyclization process was faster and provided the corresponding substituted 2-acetylbenzofurans 1a-1f. Among the latter, naturally occurring compounds calebertin (1a), caleprunin A (1b), and caleprunin B (1c) were prepared in good overall yields. These benzofurans were also obtained by direct treatment under MW irradiation of the precursors 1-aryloxypropan-2-ones 7a-7c with DMFDMA, followed by addition of the catalyst, resulting in a route that was one step shorter.

Synthesis of 1,1,1-trichloro-2,2-bis-(carboxymethoxyaryl)ethanes as potential antimicrobial and insecticidal agents

Some new 1,1,1-trichloro-2,2-bis-(carboxymethoxyaryl)-ethanes 2a-t have been synthesised by the treating aryloxyacetic acid (two moles) with chloral hydrate (1 mole) in the presence of catalytic amount of conc. sulphuric acid. The aryloxyacetic acid are prepared by the reaction of substituted phenols with chloroacetic acid in the presence of aq. sodium hydroxide. The antimicrobial activity of these compounds have been assayed against various Gram+ve, Gram-ve bacteria and fungi. The constitution of the products have been elucidated by IR, 1H NMR and mass spectral data and elemental analyses.