95450-80-9

Upstream product

• 95-87-4 2,5-Dimethylphenol 
• 96-32-2 bromoacetic acid methyl ester 
• 67-56-1 methanol 
• 7356-41-4 2,5-dimethylphenoxyacetic acid 

Downstream Products

• 95450-57-0 (Z)-2-(2,5-Dimethyl-phenoxy)-3-hydroxy-but-2-enedioic acid dimethyl ester 
• 93-86-7 2-(2,5-dimethylphenoxy)ethan-1-ol 

Relevant academic research and scientific papers

Preparation method of anti-proliferation reactive intermediate ML-098

The invention discloses a preparation method of an anti-proliferation reactive intermediate ML-098 with the chemical name of 1-(2-(2,5-dimethyl phenoxy)ethyl)-3-indolecarboxylic acid, and belongs to the field of a chemical medicine intermediate. The metho

An efficient synthesis of benzofurans and their application in the preparation of natural products of the genus Calea

The intramolecular cyclization of the β-substituted olefins methyl 2-aryloxy-3-dimethylaminopropenoates 3a-3f catalyzed by Lewis acids leads to a short and novel synthesis of benzofurans 2a-2f. When the olefins 4-dimethylamino-3-aryloxy-3-buten-2-ones 4a-4f were used, the cyclization process was faster and provided the corresponding substituted 2-acetylbenzofurans 1a-1f. Among the latter, naturally occurring compounds calebertin (1a), caleprunin A (1b), and caleprunin B (1c) were prepared in good overall yields. These benzofurans were also obtained by direct treatment under MW irradiation of the precursors 1-aryloxypropan-2-ones 7a-7c with DMFDMA, followed by addition of the catalyst, resulting in a route that was one step shorter.

Captodative olefins: Methyl 2-aryloxy-3-dimethyl-aminopropenoates and their application in a new synthesis of benzofurans

The β-substituted captodative olefins methyl 2-aryloxy-3- dimethylaminopropenoates 4a-h were synthesized, via aminomethylenation of the corresponding 2-phenoxyacetic esters 9a-h. Lewis acid promoted intramolecular cyclization of alkenes 4 led to benzofurans 7a-h, in an efficient synthetic approach to the benzofuran frame.

Le polyphosphate d'ethyle, un reactif de choix pour la synthese de derives du benzofuranne dicarboxylate-2,3 de methyle

The aim of this work is to develop a fast and effective method for the synthesis of methylated derivatives of dimethylbenzofuran-2,3-dicarboxylate.With this end in view, we can suggest significant improvements to the Koelsch and Whitney method, especially by using ethyl polyphosphate.This reagent is indeed well adapted to the cyclodehydration of the methyl 2-aryloxy-3-hydroxymaleate intermediates into benzofuran compounds, since the yield is often better than 80percent.