73576-44-0Relevant academic research and scientific papers
Aplysamine-1 and related analogs as histamine H3 receptor antagonists
Swanson, Devin M.,Wilson, Sandy J.,Boggs, Jamin D.,Xiao, Wei,Apodaca, Richard,Barbier, Ann J.,Lovenberg, Timothy W.,Carruthers, Nicholas I.
, p. 897 - 900 (2006)
Aplysamine-1 (1), a marine natural product, was synthesized and screened for in vitro activity at the human and rat histamine H3 receptors. Aplysamine-1 (1) was found to possess a high binding affinity for the human H3 receptor (Ki = 30 ± 4 nM). Synthetic analogs of 1, including des-bromoaplysamine-1 (10) and dimethyl-{2-[4-(3-piperidin-1-yl- propoxy)-phenyl]-ethyl}-amine (13), were potent H3 antagonists.
