7358-62-5

Basic information

• Product Name: 1,3-Dimethyl-5-isopropylbarbituric acid
• Synonyms: 1,3-Dimethyl-5-isopropylbarbituric acid
• CAS NO: 7358-62-5
• Molecular Formula: C₉H₁₄N₂O₃
• Molecular Weight: 198.22
• Mol File: 7358-62-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 108.5-109.5 °C
• Boiling Point: 264.4°C at 760 mmHg
• Flash Point: 102.7°C
• Appearance: /
• Density: 1.164g/cm³
• Vapor Pressure: 0.00973mmHg at 25°C
• Refractive Index: 1.49
• PKA: 5.11±0.50(Predicted)
• CAS DataBase Reference: 1,3-Dimethyl-5-isopropylbarbituric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dimethyl-5-isopropylbarbituric acid(7358-62-5)
• EPA Substance Registry System: 1,3-Dimethyl-5-isopropylbarbituric acid(7358-62-5)

Safety Data

• Hazardous Substances Data: 7358-62-5(Hazardous Substances Data)

Usage

General Description

1,3-Dimethyl-5-isopropylbarbituric acid, also known as amobarbital, is a barbiturate compound with sedative, hypnotic, and anesthetic properties. It is commonly used as a short-term treatment for insomnia and as a preoperative medication to induce sleep and reduce anxiety. Amobarbital works by depressing the central nervous system, slowing down brain activity, and inducing relaxation and sleep. However, it also carries potential risks of addiction, tolerance, and dependence, and can cause respiratory depression and other serious side effects. Due to its potential for abuse and addiction, it is classified as a controlled substance in many countries and is regulated and prescribed with caution.

InChI:InChI=1/C9H14N2O3/c1-5(2)6-7(12)10(3)9(14)11(4)8(6)13/h5-6H,1-4H3

Upstream product

• 75-30-9 2-iodo-propane 
• 769-42-6 1,3-dimethylbarbituric acid 
• 67-63-0 isopropyl alcohol 
• 67-64-1 acetone 
• 601-79-6 isopropylmalonic acid 
• 96-31-1 N,N'-Dimethylurea 

Relevant articles and documents

Method for preparing barbituric acid hydrocarbylation derivative by using ferrous complex

The invention relates to a method for preparing a barbituric acid hydrocarbylation derivative by using a ferrous complex, which comprises the steps of carrying out coupling reaction at room temperature by using barbituric acid and alcohol as raw materials and the ferrous complex containing an ortho-carboryl benzothiazole structure as a catalyst to prepare the barbituric acid hydrocarbylation derivative. Compared with the prior art, the method has the advantages that the ferrous complex containing the ortho-carboryl benzothiazole structure is applied to catalysis of coupling reaction of barbituric acid and alcohol, the barbituric acid hydrocarbylation derivative is prepared by a one-pot method, the barbituric acid hydrocarbylation derivative is synthesized by using simple, easily available and cheap raw materials at room temperature, and the method has the advantages of low catalyst use equivalent, mild reaction conditions, high substrate universality and high yield.

Reductive C-alkylation of barbituric acid derivatives with carbonyl compounds in the presence of platinum and palladium catalysts

Effective synthetic procedures for the preparation of mono- and di-C-alkylated barbituric acid derivatives through palladium and platinum catalytic hydrogenation of solutions of barbituric acids (unsubstituted, N-mono, and N,N′-disubstituted barbituric acids) and carbonyl compounds (aliphatic and aromatic aldehydes and ketones).