73593-56-3Relevant academic research and scientific papers
Facile preparation of 1,2-diketones
Nowak, Pawel,Malwitz, David,Cole, Derek C.
, p. 2164 - 2171 (2010)
Easily accessible lead-like libraries of heterocyclic molecules useful for high-throughput screening are of continuous interest to the pharmaceutical industry. A number of drug-like libraries are derived from aromatic 1,2-diketones; however, nonsymmetrical 1,2-diketones are challenging to prepare. This communication describes a simple and practical synthesis of 1,2-diketones based on a controlled cross benzoin-like condensation reaction. Copyright Taylor & Francis Group, LLC.
Synthesis of fluoroorganic O-(Trirnethylsilyl)cyanhydrines
Sander, Michael,Sundermeyer, Wolfgang
, p. 296 - 306 (2007/10/03)
Fluororganic and/or sterically hindered cyanohydrines are useful synthetic reagents, not readily available directly from e.g. aldehydes or ketones and hydrogen cyanide. By using trimethylsilyl cyanide (TMSCN), the obtained O-Silyl-cyanohydrines can be app
Trimethylsilyl Cyanide - A Reagent for Umpolung, III: Nucleophilic Acylation of α,β-Unsaturated Carbonyl Compounds with directed 1,2-/1,4-Additions by Solvent Effects
Huenig, Siegfried,Wehner, Gregor
, p. 302 - 323 (2007/10/02)
The anion 7 of O-(trimethylsilyl)cyanohydrine 6, derived from benzaldehyde, attacks numerous α-enones in ether exclusively by 1,4-addition, even if C-3 is alkyl-substituted.In THF and DME the 1,2-adduct is formed predominantly; on addition of HMPT or 12-c
