73609-53-7

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 2799-07-7 S-trityl-L-cysteine 
• 27486-87-9 N-acetyl-S-trityl-L-cysteine 

Downstream Products

• 311343-00-7 N-(N-acetyl-S-trityl-L-cysteinyl)-S-acetylcysteamine 
• 311343-03-0 N-(N-acetyl-S-trityl-L-cysteinyl)-S-benzoylcysteamine 
• 311343-02-9 N-(N-acetyl-S-trityl-L-cysteinyl)-S-pivaloylcysteamine 
• 1422468-28-7 C₅₂H₅₆N₄O₈S 
• 312304-27-1 N-(N-acetyl-L-cysteinyl)-S-benzoylcysteamine 
• 311343-11-0 I 152 
• 681144-89-8 N-(N-acetyl-S-trityl-L-cysteinyl)-S-isobutyrylcysteamine 

Relevant academic research and scientific papers

Substrate-initiated synthesis of cell-penetrating poly(disulfide)s

Lessons from surface-initiated polymerization are applied to grow cell-penetrating poly(disulfide)s directly on substrates of free choice. Reductive depolymerization after cellular uptake should then release the native substrates and minimize toxicity. In the presence of thiolated substrates, propagators containing a strained disulfide from asparagusic or, preferably, lipoic acid and a guanidinium cation polymerize into poly(disulfide)s in less than 5 min at room temperature at pH 7. Substrate-initiated polymerization of cationic poly(disulfide)s and their depolymerization with dithiothreitol causes the appearance and disappearance of transport activity in fluorogenic vesicles. The same process is further characterized by gel-permeation chromatography and fluorescence resonance energy transfer.

Synthesis of new N-isobutyryl-l-cysteine/MEA conjugates: Evaluation of their free radical-scavenging activities and anti-HIV properties in human macrophages

Four novel N-isobutyryl-l-cysteine/2-mercaptoethylamine (MEA, cysteamine) conjugates have been designed and synthesized. The antioxidant activities of these new series were evaluated by three different free radical scavenging methods (DPPH test, ABTS test

Novel antioxidants, preparation processes and their uses

The invention concerns a process for preparing compounds of general formula (I) wherein R and R′ represent an alkyl radical or an aryl group; and R″ is hydrogen or a CO—R1 group wherein R1 is an alkyl radical or an aryl group; and wherein these compounds are or not in the thiazolidine form; by protecting the N-acyl-L-cysteine to form an intermediate compound; and then by coupling said intermediate compound with S-acylcysteamine hydrochloride or with thiazolidine.

Synthesis and Biological Evaluation in Human Monocyte-Derived Macrophages of N-(N-Acetyl-L-cysteinyl)-S-acetylcysteamine Analogues with Potent Antioxidant and Anti-HIV Activities

We synthesized a series of N-(N-acetyl-L-cysteinyl)-S-acetylcysteamine (10) analogues bearing various acyl groups on thiol cysteine or cysteamine residues, to investigate the structure-activity relationship for pro-GSH and anti-HIV properties in human mac

NAC/MEA conjugate: A new potent antioxidant which increases the GSH level in various cell lines

I-152 is a prodrug of NAC and MEA with potent pro-GSH effects in human macrophages, astrocytes and lymphocytes. This molecule could be of interest in HIV infection in respect to its antioxidant and anti-HIV activities, but also in other diseases to counte

A-Acetyl-arginine-vasopressin, an Interesting Antagonist of the Vasopressor Response to Vasopressin

The synthesis of N-acetyl-arginine-vasopressin was undertaken utilizing a combination of the stepwise active ester and fragment condensation methods.Ac-Tyr(Me)AVP is an antagonist of the vasopressor response to vasopr