736150-30-4Relevant academic research and scientific papers
Synthesis and antibacterial activity of a novel series of DNA gyrase inhibitors: 5-[(E)-2-arylvinyl]pyrazoles
Tanitame, Akihiko,Oyamada, Yoshihiro,Ofuji, Keiko,Terauchi, Hideo,Kawasaki, Motoji,Wachi, Masaaki,Yamagishi, Jun-Ichi
, p. 4299 - 4303 (2007/10/03)
The 2-arylvinyl moiety in 1-(3-chlorophenyl)-3-(4-piperidyl)-5-[(E)-2-(5- chloro-1H-indol-3-yl)vinyl]pyrazole 2, which has previously shown improved DNA gyrase inhibition and target-related antibacterial activity, was transformed to other groups and the i
Synthesis and antibacterial activity of a novel series of potent DNA gyrase inhibitors. Pyrazole derivatives
Tanitame, Akihiko,Oyamada, Yoshihiro,Ofuji, Keiko,Fujimoto, Mika,Iwai, Noritaka,Hiyama, Yoichi,Suzuki, Kenji,Ito, Hideaki,Terauchi, Hideo,Kawasaki, Motoji,Nagai, Kazuo,Wachi, Masaaki,Yamagishi, Jun-Ichi
, p. 3693 - 3696 (2007/10/03)
We have previously found that a pyrazole derivative 1 possesses antibacterial activity and inhibitory activity against DNA gyrase and topoisomerase IV. Here, we synthesized new pyrazole derivatives and found that 5-[(E)-2-(5-chloroindol-3-yl)vinyl]pyrazol
