73621-35-9

Upstream product

• 43192-31-0 2-bromo-4-methoxybenzaldehyde 
• 126726-62-3 2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 73621-27-9 2-(2-Isopropenyl-4-methoxy-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 64957-84-2 4,5-dihydro-2-(2',4'-dimethoxyphenyl)-4,4-dimethyloxazole 

Downstream Products

• 86498-78-4 (E)-1-(2-Isopropenyl-4-methoxy-phenyl)-4-(2-trimethylsilanyl-ethyl)-hexa-3,5-dien-1-ol 

Relevant academic research and scientific papers

Construction of Partially Protected Nonsymmetrical Biaryldiols via Semipinacol Rearrangement of o-NQM Derived from Enynones

The construction of partially protected nonsymmetrical biaryldiols catalyzed by AgBF4 has been achieved. The approach facilitates the formation of two new aryl rings and the introduction of two hydroxyl groups (one free and one TBS-protected) via the o-NQM generation/semipinacol rearrangement cascade, featuring high atom- and step-economy to afford a diverse array of partially protected nonsymmetrical biaryldiols under mild conditions.

Asymmetric Induction in Hydroacylation by Cooperative Iminium Ion-Transition-Metal Catalysis

A new strategy for the rhodium-catalyzed enantioselective hydroacylation is described. This has been achieved through the merger of iminium ion catalysis and transition-metal catalysis such that asymmetric induction derives from a readily accessible, inexpensive chiral nonracemic secondary amine catalyst rather than a chiral nonracemic phosphine as is typical of conventional asymmetric hydroacylation methods.