64957-84-2Relevant academic research and scientific papers
4-Cyanophenols bearing metabolically robust substituents
Johnson, Patrick S.,Underwood, Toby J.,Wheeler, Simon
scheme or table, p. 3226 - 3227 (2011/06/28)
We report a variety of synthetic strategies to access novel 4-cyanophenols bearing substituents expected to be resistant to metabolism.
Photochromic properties of new benzoindene-fused 2H-chromenes
Martins, Cristina I.,Coelho, Paulo J.,Carvalho, Luis M.,Oliveira-Campos, Ana M.F.,Samat, Andre,Guglielmetti, Robert
, p. 570 - 578 (2007/10/03)
The synthesis and the photochromic properties of new photochromic 6,7- and 7,8-benzoindene annellated benzopyrans are described. When compared to parent indeno-fused 2H-chromenes (2H-[1]benzopyrans), compounds 10 and 12 exhibit a significant bathochromic shift of maximum-absorption wavelength, an increase in the colorability, and similar fading rates.
Synthesis of Substituted Fluorenones and Substituted 3',3'-Dichlorospiro and Their Reactivities
Chew, Warren,Hynes, Rosemary C.,Harpp, David N.
, p. 4398 - 4404 (2007/10/02)
Several novel 9-fluorenones were synthesized and were used as precursors in an attempt to prepare unique substituted 3',3'-dichlorospiro.Several of the thiiranes were unstable and desulfurized during their preparation (7a-d, 11, 12). 3',3'-Dichloro(2,5-dimethoxyspiro (7f) was prepared along with 2,2-dichloro-3,3-bis(4-methoxyphenyl)thiirane (16), and 3',3'-dichloro-10,11-dihydrospirocycloheptane-5,2'-thiirane> (17) all of which were stable at room temperature.A study of the reactivity of fluorenyl-substituted thiiranes and other related thiiranes showed that the extent of aromaticity of the substituents at the 3-position of the thiiranes influences their stabilities.
A convenient synthesis of N-methyl-3-(2-ethenylphenyl)-1(2H)-isoquinolones, key models for the elaboration of the benzo[c] phenanthridinone and phenanthridine skeletons
Couture, Axel,Cornet, Helene,Grandclaudon, Pierre
, p. 8097 - 8100 (2007/10/02)
A variety of N-methyl-3-(2-ethenylphenyl)-1(2H)-isoquinolones 1a-e have been prepared by base-induced intramolecular cyclization of N-(2-ethenylbenzoyl)-N,2-dimethylbenzamide derivatives 2a-e. The concomitant formation of the fused dihydro benzo[c]phenant
Leukotriene antagonists
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, (2008/06/13)
This invention provides tricyclic derivatives which are leukotriene B4 antagonists, formulations of those derivatives, and a method of using those derivatives for the treatment of conditions characterized by an excessive release of leukotrienes
Hydroxyacetophenone-derived antagonists of the peptidoleukotrienes
Brown,Bersntein,Cronk,Dossett,Hebbel,Maduskuie Jr.,Shapiro,Vacek,Yee,Willard,Krell,Snyder
, p. 807 - 826 (2007/10/02)
Considerations of the possible similarities between leukotriene D4 and its prototypical antagonist, FPL 55712, led to the development of a new series of leukotriene antagonists incorporating a hydroxyacetophenone group (e.g., the toluic acids 1
3,6-Dimethoxyfluorenylidene: A Ground-State Singlet Carbene
Chuang, Carl,Lapin, Stephen C.,Schrock, Alan K.,Schuster, Gary B.
, p. 4238 - 4243 (2007/10/02)
Irradiation of 3,6-dimethoxy-9-diazofluorene gives 3,6-dimethoxy-9-fluorenylidene.This carbene was detected in frozen media by low-temperature optical spectroscopy and at room temperature in fluid solution by nanosecond laser techniques.The EPR spectrum o
