7363-99-7

Basic information

• Product Name: 1,1-dichloro-2-ethoxycyclopropane
• Synonyms: 1,1-dichloro-2-ethoxycyclopropane
• CAS NO: 7363-99-7
• Molecular Formula: C₅H₈Cl₂O
• Molecular Weight: 155
• Mol File: 7363-99-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 172.1°C at 760 mmHg
• Flash Point: 64.9°C
• Appearance: /
• Density: 1.25g/cm³
• Vapor Pressure: 1.81mmHg at 25°C
• Refractive Index: 1.473
• CAS DataBase Reference: 1,1-dichloro-2-ethoxycyclopropane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-dichloro-2-ethoxycyclopropane(7363-99-7)
• EPA Substance Registry System: 1,1-dichloro-2-ethoxycyclopropane(7363-99-7)

Safety Data

• Hazardous Substances Data: 7363-99-7(Hazardous Substances Data)

Usage

General Description

1,1-dichloro-2-ethoxycyclopropane is a specific organic chemical compound that belongs to the family of organochlorine compounds - those containing carbon-chlorine bonds. This chemical structure is a cyclopropane ring, a triangular arrangement of three carbon atoms, with two chlorines attached to one carbon, and an ethoxy group (an oxygen with an ethyl group attached) on a second carbon. It is a potent chemically reactive molecule that has applications in various organic chemical syntheses. As with many organochlorines, it is important to handle it with proper safety precautions due to its reactivity and potential toxicity.

InChI:InChI=1/C5H8Cl2O/c1-2-8-4-3-5(4,6)7/h4H,2-3H2,1H3

Upstream product

• 67-66-3 chloroform 
• 109-92-2 ethyl vinyl ether 
• 75-87-6 chloral 

Downstream Products

• 10602-34-3 1,1-diethoxy-but-2-ene 
• 42198-64-1 trans-ethoxy-1-chloro-2-cyclopropane 
• 42198-64-1 cis-ethoxy-1-chloro-2-cyclopropane 
• 7575-33-9 2-chloroprop-2-enal diethyl acetal 

Relevant articles and documents

Multivariate optimization of a cyclopropanation, the key step in the synthesis of 3,3,4,4-tetraethoxybut-1-yne

3,3,4,4-Tetraethoxybut-1-yne (TEB) is a versatile synthon that can be produced in a four-step synthesis. The third step of the synthesis is a cycloproanation, which has been thoroughly investigated and optimized by means of statistical experimental design and multivariate modeling. At the outset, an exhaustively pre-experimental design was performed resulting in a copious Ishikawa cause-effect diagram. In total six of the experimental variables were assessed to be of large importance and thus selected for further investigation by fractional factorial design. The results of that screening and first step optimization formed the basis for a response surface modeling (RSM) study. The RSM investigation was completed by using a central composite design from which a response surface was graphically produced as an iso-contour projection. The derived multivariate predictive model in terms the iso-contour projection plots were ultimately utilized to establish experimental conditions that concomitantly provided excellent yield (>99%) and minimized amounts of inputs and thus obtain the desired product at the lowest production cost and minimized side-streams.

SYNTHESIS AND BIOLOGICAL ACTIVITY OF GEM-DICHLOROCYCLOPROPYL ETHERS

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