7365-83-5Relevant academic research and scientific papers
Synthesis of substituted 2-(2-oxopyrrolidin-1-yl)acetamides
Kavina,Sizov,Yakovlev
, p. 873 - 878 (2017/08/02)
The reaction of chloroacetamide with 2 equiv of γ-aminobutyric acid potassium salts provides a convenient method for the synthesis of substituted 4-[(2-amino-2-oxoethyl)amino]butanoic acids. Alkylation products of 2-aminoacetic and 3-aminopropanoic acid with chloroacetamide were isolated. Thermal cyclization of substituted 4-[(2-amino-2-oxoethyl)amino]butanoic acids afforded 2-(2-oxopyrrolidin-1-yl)acetamides.
Influence de composes a heterocycle azote et particulierement d'azoles non condenses sur des reactions "prebiotiques" de condensation d'acides α-amines induites par les polyphosphates an milieu aqueux
Rabinowitz, Joseph,Hampai, Aioub
, p. 962 - 966 (2007/10/02)
In previous experiments aqueous solutions of α-aminoacids in the presence of cyclic or linear polyphosphates, pH range 7-11, yielded up to 40percent of dipeptide but only 0.3-0.5percent of tripeptide .By addition of imidazole the yield of tripeptide could be increased about ten times .Therefore, we have studied for the condensation reaction of glycine the influence of the addition to aqueous solutions 0.1M in glycine and 0.1M in trimethaphosphate at room temperature, pH range 6.7-8.9, of several azoles (pyrrole, pyrazole, imidazole, 1,2,4-triazole and tetrazole), of adenine, guanine, uracil, cytosine, and of several nucleosides (adenosine, guanoside, uridine and cytydine).Among the produts studied, only 1,2,4-triazole and imidazole improve appreciably, by a factor of about 15, the yield of triglycine (up to 7.8percent).While it is very likely that imidazole has played an important role during prebiotic chemical evolution, it is not clear at present whether 1,2,4-triazole has a prebiotic significance.
