73660-77-2Relevant academic research and scientific papers
The Reformatsky Type Reaction of Gilman and Speeter in the Preparation of Valuable β-Lactams in Carbapenem Synthesis: Scope and Synthetic Utility
Palomo, Claudio,Cossio, Fernando P.,Arrieta, Ana,Odriozola, Jose M.,Oiarbide, Mikel,Ontoria, Jesus M.
, p. 5736 - 5745 (2007/10/02)
The preparation of apppropriately substituted 3-alkyl β-lactams from the Reformatsky type reaction of Gilman and Speeter is described.Treatment of Schiff bases derived from α-methylcinnamaldehyde and amines with ethyl α-bromobutyrate or ethyl α-bromoisova
The α-Bromoester-Imine Condensation promoted by Zinc-Trimethylchlorosilane: A Stereospecific Short Formal Synthesis of (+/-)-Carbapenem Antibiotics and Realated Compounds
Cossio, Fernando P.,Odrizola, Jose M.,Oiarbide, Mikel,Palomo, Claudio
, p. 74 - 76 (2007/10/02)
Ethyl bromoacetate reacts with imines in the presence of zinc activated by trimethylchlorosilane to give high yields of 3-unsubstituted β-lactams.
