73663-58-8

Upstream product

• 73663-61-3 5-(3,4-Dimethoxyphenyl)oxazole 
• 32161-30-1 (S)-3,4-dimethoxyphenylalanine 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 861597-70-8 (3,4-dimethoxy-phenyl)-acetic acid-(3,4-dimethoxy-phenacylamide) 
• 108-88-3 toluene 
• 10025-87-3 trichlorophosphate 
• 73663-56-6 (3,4-Dimethoxy-phenyl)-[5-(3,4-dimethoxy-phenyl)-oxazol-2-yl]-methanol 

Downstream Products

• 139-76-4 N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide 

Relevant academic research and scientific papers

Dimerization of Phenylalanine: An Approach to Thiazoles and Oxazoles Involved S/O-Insertion

We herein describe the development of a dimerization procedure for amino acids to prepare 2,5-disubstituted thiazoles and oxazoles in the presence of Na2S?9H2O and H2O, respectively. These approaches enabled the direct formation of five-membered ring systems bearing two different heteroatoms from two amino acid units. Mechanically, decarboxylation, deamination, S/O insertion, cyclization and gradient oxidation processes were involved in the oligomer formation. (Figure presented.).

Oxazoles in Organic Chemistry. 2. Application to the Synthesis of Benzylisoquinoline Alkaloids

A conceptually new route to the benzylisoquinoline alkaloids has been devised.The reaction of 2-lithiooxazoles with aromatic aldehydes to generate the thermodynamically favored 2-substituted oxazoles constitutes the key step in this process.A single-pot two carbon-carbon bond-joining reaction leading to an oxazoline suitable for further transformation to a phenethylamide is also described.