73663-61-3

Basic information

• Product Name: Oxazole, 5-(3,4-dimethoxyphenyl)-
• Synonyms: Oxazole,5-(3,4-dimethoxyphenyl);5-(3,4-Dimethoxyphenyl)oxazole
• CAS NO: 73663-61-3
• Molecular Formula: C11H11NO3
• Molecular Weight: 205.213
• Mol File: 73663-61-3.mol

Chemical Properties

• Melting Point: 100-102 °C(Solv: heptane (142-82-5))
• Boiling Point: 318.0±32.0 °C(Predicted)
• Density: 1.148±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Oxazole, 5-(3,4-dimethoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 5-(3,4-dimethoxyphenyl)-(73663-61-3)
• EPA Substance Registry System: Oxazole, 5-(3,4-dimethoxyphenyl)-(73663-61-3)

Safety Data

• Hazardous Substances Data: 73663-61-3(Hazardous Substances Data)

Upstream product

• 288-42-6 oxazol 
• 2859-78-1 4-Bromoveratrole 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 73663-56-6 (3,4-Dimethoxy-phenyl)-[5-(3,4-dimethoxy-phenyl)-oxazol-2-yl]-methanol 
• 70216-32-9 5-(3,4-dimethoxyphenyl)-2-phenyl-1,3-oxazole 
• 1206483-03-5 5-(3,4-dimethoxy-phenyl)-2-phenylethynyl-oxazole 
• 1218811-79-0 5-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)ethynyl]oxazole 
• 1258619-28-1 5-(3,4-dimethoxyphenyl)-2-n-octyloxazole 
• 1264661-11-1 5-(3,4-dimethoxyphenyl)-2-[2-(pyridin-2-yl)phenyl]oxazole 
• 1613376-87-6 C₂₈H₂₃NO₃ 
• 1435232-18-0 (E)-4-(2-(5-(3,4-dimethoxyphenyl)oxazol-2-yl)vinyl)benzonitrile 
• 1435234-12-0 3-[5-(3,4-dimethoxyphenyl)-2-oxazolyl]pyridine 
• 1394840-51-7 C₁₅H₁₁NO₅ 
• 1394840-87-9 C₁₉H₁₉NO₅ 
• 1170659-62-7 5-(3,4-dimethoxyphenyl)-2-{4-(phenylethynyl)phenyl}oxazole 
• 1170659-56-9 methyl 4-{5-(3,4-dimethoxyphenyl)oxazol-2-yl}benzoate 
• 1170659-57-0 4-{5-(3,4-dimethoxyphenyl)oxazol-2-yl}benzonitrile 

Relevant articles and documents

Improvement of the Van Leusen reaction in the presence of β-cyclodextrin: A green and efficient synthesis of oxazoles in water

An efficient approach for the synthesis of oxazoles through the Van Leusen reaction in the presence of β-cyclodextrin is described. In aqueous medium using β-cyclodextrin as a supramolecular catalyst, tosylmethyl isocyanide was deprotonated by triethylami

Mild palladium-catalyzed regioselective direct arylation of azoles promoted by tetrabutylammonium acetate

A mild, general, and convenient palladium-catalyzed direct arylation of the 5-position of azoles with aryl bromides, efficiently promoted by tetrabutylammonium acetate, is described. 1-Methylpyrazole, oxazole, and thiazole reacted at 70°C in N,N-dimethyla

Synthesis and evaluation of photophysical properties of Series of π-conjugated oxazole dyes

Incorporation of π-conjugated spacers at the 2 or 5 position of a 2,5-disubstitutedaryloxazole led to new series of fluorescent dyes. They show emissions from visible to 700 nm along with significant Stokes shift up to 208 nm and a strong solvatochromic fluorescence. These compounds are easily accessible in one step through direct C-H bond functionalization.

Copper-mediated dehydrogenative biaryl coupling of naphthylamines and 1,3-azoles

A copper-mediated dehydrogenative biaryl cross-coupling of naphthylamines and 1,3-azoles has been developed. The key to its success is the introduction of N,N-bidentate coordination system based on the picolinamide directing group. The reaction proceeds s

COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

Compounds and their pharmaceutically acceptable salts for treatment of synucleinopathies, such as Parkinson's disease and tauopathies.

Copper-mediated intermolecular direct biaryl coupling

Copper-mediated intermolecular direct biaryl coupling of arylazines and azoles via dual C-H bond cleavage proceeds even without palladium catalysts. The reaction system shows the high potential of copper salts in direct C-H arylation chemistry and provides a new approach to biaryl motifs, which are ubiquitous in pharmaceuticals and functional materials.

1,1-dibromo-1-alkenes as valuable partners in the copper-catalyzed direct alkynylation of azoles

The copper-catalyzed direct alkynylation of azoles with 1,1-dibromo-1-alkenes as electrophiles is described. These easily accessible substrates are a useful addition to the field of direct alkynylations in an efficient and functional group tolerant reaction to provide a straightforward entry to diverse alkynyl heterocycles.

Synthesis of 2,5-diaryloxazoles through van Leusen reaction and copper-mediated direct arylation

The direct arylation of 5-aryloxazoles, prepared by the van Leusen reaction, with various aryl iodides is effectively promoted by a system of CuI combined with PPh3 and Na2CO3 as a ligand and a base, respectively, in DMF to produce the corresponding 2,5-diaryloxazoles in good yields.

Ligandless microwave-assisted Pd/Cu-catalyzed direct arylation of oxazoles

(Chemical Equation Presented) An efficient microwave-assisted palladium/copper co-mediated direct arylation of oxazoles with aryl bromides under ligandless conditions has been developed. The method is functional group tolerant and provides rapid access to medicinally relevant compounds in good yields. Coupled to the van Leusen oxazole ring synthesis, this methodology is illustrated by an expedient two-step synthesis of the four 2,5-diaryloxazole alkaloids texamine, texaline, balsoxin, and O-Me-halfordinol from commercially available starting materials.