70216-32-9

Basic information

• Product Name: 5-(3,4-dimethoxyphenyl)-2-phenyl-1,3-oxazole
• Synonyms: 5-(3,4-dimethoxyphenyl)-2-phenyl-1,3-oxazole;2-Phenyl-5-(3,4-dimethoxyphenyl)oxazole;Balsoxin;Balsoxine
• CAS NO: 70216-32-9
• Molecular Formula: C₁₇H₁₅NO₃
• Molecular Weight: 0
• Mol File: 70216-32-9.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 432.468°C at 760 mmHg
• Flash Point: 215.349°C
• Appearance: /
• Density: 1.153g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: 5-(3,4-dimethoxyphenyl)-2-phenyl-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3,4-dimethoxyphenyl)-2-phenyl-1,3-oxazole(70216-32-9)
• EPA Substance Registry System: 5-(3,4-dimethoxyphenyl)-2-phenyl-1,3-oxazole(70216-32-9)

Safety Data

• Hazardous Substances Data: 70216-32-9(Hazardous Substances Data)

Usage

Occurrence

Amyris balsamifera yields this alkaloid. It crystallizes as colourless needles from EtOH.

InChI:InChI=1/C17H15NO3/c1-19-14-9-8-13(10-15(14)20-2)16-11-18-17(21-16)12-6-4-3-5-7-12/h3-11H,1-2H3

Upstream product

• 7664-93-9 sulfuric acid 
• 70216-33-0 N-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)benzamide 
• 108-86-1 bromobenzene 
• 73663-61-3 5-(3,4-Dimethoxyphenyl)oxazole 
• 1133215-77-6 2,5-bis(methylthio)oxazole 
• 28557-00-8 phenylzinc chloride 
• 591-50-4 iodobenzene 
• 61650-22-4 N-(pivaloyloxy)benzamide 
• 4302-52-7 4-ethynylveratrole 
• 66003-78-9 triphenylsulfonium trifluoromethanesulfonate 
• 100-52-7 benzaldehyde 
• 1835-02-5 2-Bromo-1-(3,4-dimethoxyphenyl)ethanone 
• 100-46-9 benzylamine 
• 2835-06-5 phenylglycin 

Downstream Products

• 90253-92-2 7-(3,4-Dimethoxybenzoyl)-2,5-diphenyl-1H,7H-s-triazolo<1,2-a>-s-triazol-1,3(2H)-dion 

Relevant articles and documents

Pd/Cu-Catalyzed C-H/C-H Cross Coupling of (Hetero)Arenes with Azoles through Arylsulfonium Intermediates

A highly efficient method for the selective formal C-H/C-H cross-coupling of azoles and (hetero)arenes was established through arylsulfonium intermediates under transition-metal catalysis, which produced a variety of 2-(hetero)aryl azoles in good to excellent yields. Advantages of the reaction included mildness, a good functional group tolerance, a wide range of substrates, a high regio- and chemoselectivity, one-pot procedures, and the late-stage functionalization of complex molecules without the use of oxidants, offering a promising strategy for the transition-metal-catalyzed C-H arylation of azoles.

Synthesis method of oxazole heterocyclic compound

The invention belongs to the technical field of organic synthesis and medicines, and particularly relates to a synthesis method of an oxazole heterocyclic compound. Aryl aldehyde and a triazole derivative are used as raw materials and are heated to react in the presence of trichloromethane and rhodium acetate catalysts to obtain the oxazole heterocyclic compound. By using the method provided by the invention, under the condition of heating and stirring, the oxazole heterocyclic derivative can be obtained at a relatively high yield after reaction for 3-12 hours. According to the method disclosed by the invention, the oxazole heterocyclic derivative is simply, conveniently and efficiently synthesized by using simple and easily available raw materials through a one-step method, and a simple and efficient new synthesis method with wide substrate universality is provided for synthesizing the oxazole heterocyclic derivative.

Synthesis of 2,5-disubstituted oxazoles: Via cobalt(III)-catalyzed cross-coupling of N -pivaloyloxyamides and alkynes

An efficient synthesis of 2,5-disubstituted oxazoles via Co(iii) catalysis is described herein. The synthesis is achieved under mild conditions through [3+2] cycloaddition of N-pivaloyloxyamides and alkynes. The reaction operates through an internal oxidation pathway and features a very broad substrate scope. The one-step synthesis of natural products such as texamine and balsoxin has been demonstrated via this protocol.