73671-44-0Relevant academic research and scientific papers
An Ultrasensitive Cyclization-Based Fluorescent Probe for Imaging Native HOBr in Live Cells and Zebrafish
Xu, Kehua,Luan, Dongrui,Wang, Xiaoting,Hu, Bo,Liu, Xiaojun,Kong, Fanpeng,Tang, Bo
, p. 12751 - 12754 (2016)
Bromine has been reported recently as being the 28thessential element for human health. HOBr, which is generated in vivo from bromide, is a required factor in the formation of sulfilimine crosslinks in collagen IV. However, to date, no method for the specific detection of native HOBr in vivo has been reported. Herein, we develop a simple small molecular probe for imaging HOBr based on a specific cyclization catalyzed by HOBr. The probe can be easily synthesized in high yield through a Suzuki cross-coupling reaction. The probe exhibits ultrahigh sensitivity at the picomole level, in addition to specificity for HOBr and real-time response. Importantly, without Br?stimulation, this probe reports native HOBr levels in HepG2 cells. Thus, the probe is a promising new tool for imaging endogenous HOBr and may provide a means for finding new physiological functions of HOBr in living organisms.
Synthesis of Ti(iv) complexes of donor-functionalised phenoxy-imine tridentates and their evaluation in ethylene oligomerisation and polymerisation
Suttil, James A.,Shaw, Miranda F.,McGuinness, David S.,Gardiner, Michael G.,Evans, Stephen J.
, p. 9129 - 9138 (2013/07/27)
A number of analogues of the Mitsui Chemicals ethylene trimerisation system (IV) have been explored, in which one of the donor atoms have been modified. Thus, a series of mono-anionic tridentate phenoxy-imine (3-(t-butyl)-2-(OH)- C6H4CN(C(CH3)2CH2OMe) 1, 3-(adamantyl)-2-(OH)-C6H4CN(2′-(2′′- (SMe)C6H4)-C6H4) 2, 3-(t-butyl)-2-(OSiMe3)-C6H4CN(C(CH 3)2CH2OMe) 3) or phenoxy-amine (3,5-di(t-butyl)-2-(OH)-C6H4CH2-N(2′- (2′′-(OMe)C6H4)-C6H4) 4) ligands have been prepared and reacted with TiCl4 or TiCl 4(thf)2 to give the mono-ligand complexes 5-7. The solid state structures of compounds 4-6 have been determined. Complexes 5-7 have been tested for their potential as ethylene oligomerisation/polymerisation systems in conjunction with MAO activator and benchmarked against the Mitsui phenoxy-imine trimerisation system IV. While the phenoxy-amine complex 6 shows a propensity for polymer formation, the phenoxy-imine complexes 5 and 7 show somewhat increased formation of short chain LAOs. Complex 5 is selective for 1-butene in the oligomeric fraction, while 7 displays liquid phase selectivity to 1-hexene. As such 7, which is a sulfur substituted analogue of the Mitsui system IV, displays similar characteristics to the parent catalyst. However, its utility is limited by the lower activity and predominant formation of polyethylene.
Cyclisation reactions of 2-substituted biphenyl-2'-yldiazonium salts leading to O-alkyldibenzofuranium and S-alkyldibenzothiophenium salts: Modified Meerwein reagents
Downie,Heaney,Kemp,King,Wosley
, p. 4005 - 4016 (2007/10/02)
The preparation of 2-amino-2'-methoxybiphenyl and 2-amino-2'-thiomethoxybiphenyl and analogues and their transformation into diazonium salts and hence into dibenzofuranium and dibenzothiophenium salts is described together with their use as alkylating agents.
Syntheses and Thermal Behaviour of 9-Substituted 9-Thia-10-azaphenanthrenes
Shimizu, Hiroshi,Ikedo, Koji,Hamada, Koji,Ozawa, Michinori,Matsumoto, Harutoshi,et al.
, p. 1733 - 1747 (2007/10/02)
Synthetic approaches to a variety of 9-thia-10-azaphenanthrenes having various kinds of substituent at the 9-position were investigated.Their thermal stabilities were found to be depend strongly upon the nature of the substituents on the sulphur atom.Seve
