73671-44-0Relevant articles and documents
An Ultrasensitive Cyclization-Based Fluorescent Probe for Imaging Native HOBr in Live Cells and Zebrafish
Xu, Kehua,Luan, Dongrui,Wang, Xiaoting,Hu, Bo,Liu, Xiaojun,Kong, Fanpeng,Tang, Bo
, p. 12751 - 12754 (2016)
Bromine has been reported recently as being the 28thessential element for human health. HOBr, which is generated in vivo from bromide, is a required factor in the formation of sulfilimine crosslinks in collagen IV. However, to date, no method for the specific detection of native HOBr in vivo has been reported. Herein, we develop a simple small molecular probe for imaging HOBr based on a specific cyclization catalyzed by HOBr. The probe can be easily synthesized in high yield through a Suzuki cross-coupling reaction. The probe exhibits ultrahigh sensitivity at the picomole level, in addition to specificity for HOBr and real-time response. Importantly, without Br?stimulation, this probe reports native HOBr levels in HepG2 cells. Thus, the probe is a promising new tool for imaging endogenous HOBr and may provide a means for finding new physiological functions of HOBr in living organisms.
Cyclisation reactions of 2-substituted biphenyl-2'-yldiazonium salts leading to O-alkyldibenzofuranium and S-alkyldibenzothiophenium salts: Modified Meerwein reagents
Downie,Heaney,Kemp,King,Wosley
, p. 4005 - 4016 (2007/10/02)
The preparation of 2-amino-2'-methoxybiphenyl and 2-amino-2'-thiomethoxybiphenyl and analogues and their transformation into diazonium salts and hence into dibenzofuranium and dibenzothiophenium salts is described together with their use as alkylating agents.
Syntheses and properties of novel cyclic sulfilimines, 2-azathiabenzene derivatives
Shimizu,Matsuo,Kataoka,Hori
, p. 4360 - 4371 (2007/10/02)
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