73675-45-3

Usage

Uses

Used in Pharmaceutical Industry:
N,N-dimethyl-2-(4-tert-butylphenoxy)ethylamine is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its versatility as a reagent in organic synthesis reactions and its ability to act as an effective catalyst make it a valuable component in the development of new drugs and medications.
Used in Organic Synthesis:
N,N-dimethyl-2-(4-tert-butylphenoxy)ethylamine is used as a reagent in organic synthesis reactions. Its solubility in a wide range of organic solvents and its ability to act as an effective catalyst contribute to its utility in the synthesis of various organic compounds.
Used in Academic Research:
N,N-dimethyl-2-(4-tert-butylphenoxy)ethylamine is used in academic research settings to study its properties and potential applications. Its versatility as a reagent and catalyst makes it an interesting subject for research in the fields of organic chemistry and pharmaceutical development.

Upstream product

• 98-54-4 para-tert-butylphenol 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 5787-50-8 sodium 4-tert-butylphenolate 
• 107-99-3 2-(dimethylamino)ethyl chloride 
• 5459-68-7 2-(N,N-dimethylamino)ethyl bromide 

Relevant academic research and scientific papers

SYNTHESIS OF POTENTIAL HERBICIDES DESIGNED TO UNCOUPLE PHOTOPHOSPHORYLATION

In a search for novel herbicides we attempted to make uncouplers of photophosphorylation.Good herbicides were discovered, but not all were good uncouplers and we present evidence which supports the view that their primary action is through inhibition of carotenoid biosynthesis.This paper describes the synthesis and in vivo and in vitro activities of 21 compounds of the series.The best herbicide was active enough to justify extensive field testing.Key Word Index - Photophosphorylation; carotenoid synthesis; inhibitors; herbicides; uncouplers; arylalkylamines.

3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION

Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using diaryloxindole compounds are described.

Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors

The growing recognition of inhibition of translation initiation as a new and promising paradigm for mechanism-based anti-cancer therapeutics is driving the development of potent, specific, and druggable inhibitors. The 3,3-diaryloxindoles were recently reported as potential inhibitors of the eIF2·GTP·Met-tRNAiMet ternary complex assembly and 3-{5-tert-butyl-2-hydroxyphenyl}-3-phenyl-1,3-dihydro-2H-indol-2- one #1181 was identified as the prototypic agent of this chemotype. Herein, we report our continuous effort to further develop this chemotype by exploring the structural latitude toward different polar and hydrophobic substitutions. Many of the novel compounds are more potent than the parent compound in the dual luciferase ternary complex reporter assay, activate downstream effectors of reduced ternary complex abundance, and inhibit cancer cell proliferation in the low μM range. Moreover, some of these compounds are decorated with substituents that are known to endow favorable physicochemical properties and as such are good candidates for evaluation in animal models of human cancer.

Steric effects in intramolecular [2+2] photocycloaddition of C=C double bonds to cyclohexenones

The effect of substituents on the mode of approach and the endo/exo ratio in intramolecular [2+2] photocycloaddition reactions were studied.