7369-91-7

Basic information

• Product Name: H-PRO-PNA HBR
• Synonyms: PROLINE-PNA HBR;(L)-PROLYL-P-NITROANILIDE;L-PRO-P-NITROANILIDE;L-PROLINE P-NITROANILIDE;L-PROLINE 4-NITROANILIDE;L-PROLINE 4-NITROANILIDE HYDROBROMIDE;H-PRO-PNA;H-PRO-PNA HBR
• CAS NO: 7369-91-7
• Molecular Formula: C₁₁H₁₃N₃O₃
• Molecular Weight: 316.15
• Product Categories: pharmacetical
• Mol File: 7369-91-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 88-90 °C
• Boiling Point: 488.5°C at 760 mmHg
• Flash Point: 249.2°C
• Appearance: /
• Density: 1.342g/cm³
• Vapor Pressure: 1.08E-09mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: -15°C
• PKA: 13.06±0.70(Predicted)
• CAS DataBase Reference: H-PRO-PNA HBR(CAS DataBase Reference)
• NIST Chemistry Reference: H-PRO-PNA HBR(7369-91-7)
• EPA Substance Registry System: H-PRO-PNA HBR(7369-91-7)

Safety Data

• Hazardous Substances Data: 7369-91-7(Hazardous Substances Data)

Usage

Chemical Properties

Light beige crystalline powder

Uses

Substrate for the determination of proline arylamidase in human sera by continuous reaction.

InChI:InChI=1/C11H13N3O3/c15-11(10-2-1-7-12-10)13-8-3-5-9(6-4-8)14(16)17/h3-6,10,12H,1-2,7H2,(H,13,15)/t10-/m0/s1

Upstream product

• 97885-49-9 tert-butyl (S)-2-((4-nitrophenyl)carbamoyl)pyrrolidine-1-carboxylate 
• 100-01-6 4-nitro-aniline 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 111492-63-8 (S)-proline acid chloride hydrochloride 
• 21027-63-4 benzyl (2S)-2-[(4-nitrophenyl)carbamoyl]pyrrolidine-1-carboxylate 

Downstream Products

• 147-85-3 L-proline 
• 60189-46-0 Arg-Pro-pNA 
• 99264-69-4 Met-Pro-pNA 
• 1169497-13-5 4-nitro-N-(((S)-pyrrolidin-2-yl)methyl)benzenamine 
• 85697-97-8 H-Tyr-Leu-Pro-pNA*HCl 
• 82155-54-2 Suc-Tyr-Leu-Pro-pNA 
• 85704-50-3 Boc-Tyr-Leu-Pro-pNA 
• 85698-09-5 H-Leu-Pro-pNA*HCl 

Relevant articles and documents

Characterisation of the aminopeptidase from non-germinated winter rape (Brassica napus L.) seeds

Rapeseed plays a crucial role in food and fuel industry. Since aminopeptidases take part in many physiological processes in all organisms, it is important to learn their role and characteristics in economically relevant plants. Extracts of non-germinated winter rape seeds were screened for aminopeptidase activity. Substrate specificity, the influence of pH and temperature, as well as effect of protease inhibitors and chosen metal ions on the aminopeptidase activity were determined. The approximate molecular weight estimated by NATIVE-PAGE and SDS-PAGE electrophoresis was ～60 kDa. The partially purified enzyme as well as the aminopeptidases present in crude extract cleaved preferentially Phe-pNA. The activity profiles toward several substrates were also determined. Maximum activity was observed at pH 6.5 and temperature of 40 °C for Phe-pNA as a substrate. Two visible picks in the pH profile toward Phe-pNA, together with other results (IEF) suggest the presence of more than one aminopeptidase, having similar molecular mass. Much lower activity and broad pH profiles were observed for Leu- and Ala-pNA as substrates.

A novel chiral aliphatic-aromatic diamine promoted direct, highly enantio- and diastereoselective Michael addition of cyclohexanone to nitroolefins under solvent-free conditions

A series of new highly efficient chiral aliphatic-aromatic diamine catalysts have been designed and successfully applied to the asymmetric Michael addition of cyclohexanone with nitroolefins under solvent-free conditions without any acidic additives. The desired adducts were obtained in high yields with excellent enantio- and diastereoselectivities of syn products (up to >99% ee, >99:1 dr).

Secondary-secondary diamine catalysts for the enantioselective Michael addition of cyclic ketones to nitroalkenes

Secondary-secondary diamines derived from S-proline are efficient catalysts for the ketone-nitroalkene Michael addition reaction. The stereoselectivity of the Michael addition is dependant on the pKa of the N-substituted aminomethyl pendant in