99264-69-4 Usage
Uses
Used in Clinical Chemistry and Medicine:
(L)-METHIONYL-(L)-PROLYL-P-NITROANILIDE is used as a diagnostic tool for identifying and differentiating liver diseases, particularly in newborns. It helps to distinguish between obstructive jaundice and jaundice caused by liver diseases, which is crucial for determining the appropriate treatment and management strategies.
Used in Research Settings:
In research, (L)-METHIONYL-(L)-PROLYL-P-NITROANILIDE serves as a valuable substrate for studying liver function and the mechanisms underlying various liver disorders. It is often used in conjunction with other biochemical markers to gain a comprehensive understanding of liver health and function, contributing to the development of novel therapeutic approaches and diagnostic methods.
Used in the Diagnosis of Inherited Liver Diseases:
(L)-METHIONYL-(L)-PROLYL-P-NITROANILIDE is employed as a diagnostic agent for inherited liver diseases, which are genetic conditions that affect the proper functioning of the liver. By measuring the activity of specific enzymes or metabolic pathways in response to this substrate, medical professionals can identify the presence of these diseases and provide appropriate care and treatment options for affected individuals.
Check Digit Verification of cas no
The CAS Registry Mumber 99264-69-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,2,6 and 4 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 99264-69:
(7*9)+(6*9)+(5*2)+(4*6)+(3*4)+(2*6)+(1*9)=184
184 % 10 = 4
So 99264-69-4 is a valid CAS Registry Number.
99264-69-4Relevant academic research and scientific papers
Zhou, Guo-Chun,Weng, Zhibing,Shao, Xiaoxia,Liu, Fang,Nie, Xin,Liu, Jinsong,Wang, Decai,Wang, Chunguang,Guo, Kai
, p. 6549 - 6554 (2013)
A series of methionine-proline dipeptide derivatives and their analogues were designed, synthesized and assayed against the serotype 2 dengue virus NS2B-NS3 protease, and methionine-proline anilides 1 and 2 were found to be the most active DENV 2 NS2B-NS3 competitive inhibitors with Ki values of 4.9 and 10.5 μM. The structure and activity relationship and the molecular docking revealed that l-proline, l-methionine and p-nitroaniline in 1 and 2 are the important characters in blocking the active site of NS2B-NS3 protease. Our current results suggest that the title dipeptidic scaffold represents a promising structural core to discover a new class of active NS2B-NS3 competitive inhibitors.
