73692-51-0

Usage

Uses

Used in Pharmaceutical Industry:
2',4',6',3,4-PENTAHYDROXYCHALCONE is used as a pharmaceutical agent for its potential therapeutic effects. Due to its unique structure and functional groups, it can interact with various biological targets and modulate signaling pathways, making it a promising candidate for the development of new drugs.
Used in Cosmetic Industry:
2',4',6',3,4-PENTAHYDROXYCHALCONE is used as an active ingredient in cosmetics for its potential skin benefits. Its antioxidant and anti-inflammatory properties can help protect the skin from environmental stressors and promote skin health.
Used in Food Industry:
2',4',6',3,4-PENTAHYDROXYCHALCONE can be used as a natural food additive for its potential health benefits. Its antioxidant properties can help preserve food quality and extend shelf life, while also providing additional health benefits to consumers.
Used in Agricultural Industry:
2',4',6',3,4-PENTAHYDROXYCHALCONE can be used as a natural pesticide or growth promoter in agriculture. Its bioactive properties can help protect crops from pests and diseases, while also promoting healthy growth and yield.
Overall, 2',4',6',3,4-PENTAHYDROXYCHALCONE is a versatile compound with potential applications in various industries, including pharmaceutical, cosmetic, food, and agricultural sectors. Its unique structure and biological activities make it a promising candidate for further research and development.

Upstream product

• 139-85-5 3,4-dihydroxybenzaldehyde 
• 36804-11-2 2,4,6-tri-MOM phloracetophenone 
• 6515-06-6 3,4-bis-methoxymethoxy-benzaldehyde 
• 91299-69-3 3,4,2',4',6'-pentamethoxymethoxychalcone 
• 108-73-6 3,5-dihydroxyphenol 
• 23416-69-5 caffeic acid chloride 
• 65490-09-7 2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone 
• 480-66-0 2,4,6-trihydroxyacetophenone 

Downstream Products

• 480-70-6 aureusidin 
• 552-58-9 eriodictyol 

Relevant academic research and scientific papers

Design, synthesis and bioactivity of chalcones and its analogues

The Vernohia anthelmintica L.'s extract is one of the most popular Uygur medicines used for vitiligo. It is believed that the chalcone compounds of the plant play an important role in the treatment since they may activate tyrosinase and improve melanin production. In this study, twenty-one chalcones and nine analogues were synthesized in view of three different components of chalcone (A, B ring and α, β-unsaturated carbonyl). After biological evaluation of their activity on tyrosinase in cell-free systems, the result showed that most compounds (except polyhydroxy chalcones) possess activator effect on the tyrosinase, especially for 13a–15a, 20a and 1b, which bearing a comparable activity to the positive control 8-MOP. SAR of these tyrosinase activator was summed up for the first time as well. Finally, compound 13a was found to increase melanin contents and tyrosinase activity 1.75 and 1.3 fold, respectively, compared with that of untreated murine B16 cells at the concentration of 40?μg/mL.

A natural active product process for synthesis of dihydro-quercetin (by machine translation)

The invention discloses a process for synthesizing (2R,3R)-dihydroquercetin. The process comprises the specific steps of carrying out Friedel-Crafts acylation on caffeic acyl chloride and phloroglucin which serve as raw materials, forming epoxy bonds through peroxidizing double bonds, opening cycles under acidic conditions, forming ether with phenolic hydroxyl, and carrying out separation, purification and crystallization after reaction is ended, thereby obtaining the product with high content and high purity. In the aspects of reagents and raw and auxiliary materials used during the reaction, both environment-friendliness and efficiency are taken into account. The process disclosed by the invention has the advantages of high atom economical efficiency, simple equipment and environment-friendly production procedure and has very large economic and social benefits.

Synthesis and studies on antidepressant activity of 2′,4′, 6′-trihydroxychalcone derivatives

In this study, we synthesized a series of 2′,4′,6′- trihydroxychalcone derivatives and evaluated their antidepressant activities. The results of the nine compounds showed significantly reduced times during the forced swimming test at a dose of 10 mg/kg, indicative of antidepressant activity. Among the compounds, 2-bromo-2′,4′,6′- trihydroxychalcone (3h) was found to be the most potent, and it was observed that compound 3h at dose of 10, 20, and 40 mg/kg significantly reduced the duration of immobility times in the FST and TST in mice 30 min after treatment. Springer Science+Business Media, LLC 2011.