73697-53-7Relevant academic research and scientific papers
Synthesis of Carnitine Homologues. Reactions of Tertiary Amines with Epoxy Esters
Degenhardt, Charles R.
, p. 2763 - 2766 (1980)
A series of new carnitine homologues, 4-hydroxy-5-(trialkylammonio)pentanoates (2) and 5-hydroxy-6-(trialkylammonio)hexanoates (3), has been synthesized.The key step in this synthesis was the reaction of an epoxy ester with a tertiary amine to effect epoxide opening and hydrolysis in one step.The generality of this reaction is discussed, and the synthetic approach to 2 and 3 is compared to previously published routes to carnitine and its analogues.Attempts to apply the new reaction scheme to carnitine itself are described.
