Journal of Organic Chemistry p. 2763 - 2766 (1980)
Update date:2022-07-29
Topics:
Degenhardt, Charles R.
A series of new carnitine homologues, 4-hydroxy-5-(trialkylammonio)pentanoates (2) and 5-hydroxy-6-(trialkylammonio)hexanoates (3), has been synthesized.The key step in this synthesis was the reaction of an epoxy ester with a tertiary amine to effect epoxide opening and hydrolysis in one step.The generality of this reaction is discussed, and the synthetic approach to 2 and 3 is compared to previously published routes to carnitine and its analogues.Attempts to apply the new reaction scheme to carnitine itself are described.
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Doi:10.1016/S0040-4039(01)86511-4
(1979)Doi:10.1021/ja00535a027
(1980)Doi:10.1055/s-2005-865293
(2005)Doi:10.1021/ja0319238
(2004)Doi:10.1016/0040-4020(81)80002-6
(1981)Doi:10.1021/jo01308a002
(1980)
