144665-07-6

Usage

InChI:InChI=1/C22H25F2N3O2S/c1-26(22-25-20-4-2-3-5-21(20)30-22)15-8-10-27(11-9-15)13-16(28)14-29-17-6-7-18(23)19(24)12-17/h2-7,12,15-16,28H,8-11,13-14H2,1H3/t16-/m0/s1

Upstream product

• 1425504-50-2 (S)-1-(3-(3,4-difluorophenoxy)-2-hydroxypropyl)piperidin-4-one 
• 1449846-89-2 (-)-(R)-3-(3,4-difluorophenoxy)propane-1,2-diol 
• 170876-51-4 1-(3,4-difluorophenoxy)-2,3-epoxypropane 
• 615-20-3 2-chlorobenzo[d][1,3]thiazole 
• 73733-69-4 ethyl 4-(methylamino)piperidine-1-carboxylate 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 
• 1449846-90-5 (+)-(S)-3-(3,4-difluorophenoxy)-2-hydroxypropyl 4-methylbenzenesulfonate 
• 104605-42-7 N-methyl-N-(piperidin-4-yl)-1,3-benzothiazol-2-amine 
• 1425504-49-9 1-(3-(3,4-difluorophenoxy)-2-hydroxypropyl)piperidin-4-one 
• 1425504-48-8 1-(3-chloro-2-hydroxypropyl)piperidin-4-one 
• 41661-47-6 piperidin-4-one 
• 1425504-46-6 1-(4-(benzothiazol-2-ylamino)piperidin-1-yl)-3-(3,4-difluorophenoxy)propan-2-ol 
• 74-88-4 methyl iodide 
• 1425504-47-7 1-(3,4-difluorophenoxy)-3-(4-(methylamino)piperidin-1-yl)propan-2-ol 

Relevant academic research and scientific papers

The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca2+/calmodulin-dependent kinase II

An affinity capillary electrophoresis (ACE) method to estimate apparent dissociation constants between bovine brain calmodulin (CaM) and non-peptidic ligands was developed. The method was validated reproducing the dissociation constants of a number of wel

A convenient synthesis of lubeluzole and its enantiomer: Evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells

Lubeluzole, a neuroprotective anti-ischemic drug, and its enantiomer were prepared following a convenient procedure based on hydrolytic kinetic resolution. The ee values were >99% and 96%, respectively, as assessed by HPLC analysis. The chemosensitizing e

Protecting group-free concise synthesis of (RS)/(S)-lubeluzole

Three new, concise, and protecting group-free synthetic routes for (RS)- and (S)-lubeluzole are reported in higher (46-62%) overall yields compared to the reported procedures (6-35%). The key steps involve C-N bond formation via epoxide aminolysis and nucleophilic substitution of 2-chlorobenzothiazole with suitably designed precursor amines and are performed in aqueous medium. Water offers an advantage in promoting the reactions compared to organic solvents and its role is envisaged as hydrogen-bond mediated electrophile-nucleophile dual activation.

4-[(2-benzothiazolyl)methylamino]-alpha-[(3,4-difluorophenoxy)methyl]-1-piperidineethanol

A compound of formula STR1 the racemic mixture, the (S)-form and the acid addition salts thereof, said compound having anti-stroke properties. Pharmaceutical compositions containing this compound as active ingredient and a method of preparing said compoun